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Clinical heterogeneity in the tricho-dento-osseous syndrome

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Summary

The tricho-dento-osseous syndrome (TDO syndrome) involves morphologic abnormalities of hair, teeth, and skeleton. Clinical findings of the TDO syndrome are excessively curly (fuzzy) hair, enamel hypoplasia, and skeletal findings of a generalized pattern of osseous sclerosis. We report an autosomal dominant syndrome with similar hair and teeth morphology, but with a skeletal dysplasia consisting of sclerosis and thickening of the calvarium with long bones that show subtle undertubulation but no sclerosis.

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References

  • Cole HN, Dirver JR, Girffen HK, Norris CB, Stroud G (1941) Ectodermal and mesodermal dysplasia with osseous involvement. Arch Dermatol 44:773–788

    Google Scholar 

  • Darwin C (1863) Animals and plants under domestication, vol 2. Orange Judd and Company, New York, p 393

    Google Scholar 

  • Gulmen S, Pullon PA, O'Brien LW (1976) Tricho-dento-osseous syndrome J Endod 2:117–120b

    Google Scholar 

  • Hansman CF (1966) Growth of interorbital distance and skull thickness as observed in roentgenographic measurements. Radiology 86: 87–96

    Google Scholar 

  • Jorgenson RJ, Warson RW (1973) Dental abnormalities in the tricho-dento-osseous syndrome. Oral Surg 36:693–700

    Google Scholar 

  • Lichtenstein J, Warson R, Jorgenson R, Dorst JP, McKusick VA (1972) The tricho-dento-osseous (TDO) syndrome. Am J Hum Genet 24: 569–582

    Google Scholar 

  • Melnick M, Shields ED, El-Kafrawy AH (1977) Tricho-dento-osseous syndrome: a scanning electron microscopic analysis. Clin Genet 12:17–27

    Google Scholar 

  • Porter PS, Lobitz WC (1970) Human hair: a genetic marker. Br J Dermatol 83:225–239

    Google Scholar 

  • Robinson GC, Miller J, Worth HM (1966) Hereditary enamel hypoplasia; its association with characteristic hair structure. Pediatrics 37: 498–502

    Google Scholar 

  • Sedgwick (1868) Brit and Foreign Medico-chirurg, Review, p 453

  • Thadani KI (1921) A toothless type of man. J Hered 12:87–88

    Google Scholar 

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Authors and Affiliations

  1. Department of Radiology, 2nd General Hospital, D-6790, Landstuhl, Federal Republic of Germany

    F. Quattromani

  2. Department of Periodontics and Genetics School of Dentistry, University of Texas Health Science Center, 78284, San Antonio, TX, USA

    S. D. Shapiro, R. S. Young & R. J. Jorgenson

  3. Department of Pediatrics, Brooke Army Medical Center, 78284, Fort Sam Houston, TX, USA

    J. W. Parker

  4. the Department of Radiology, Brooke Army Medical Center, 78284, Fort Sam Houston, TX, USA

    R. Blumhardt

  5. Department of Radiology, William Beaumont Army Medical Center, 79901, El Paso, TX, USA

    R. R. Reece

Authors
  1. F. Quattromani
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  2. S. D. Shapiro
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  3. R. S. Young
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  4. R. J. Jorgenson
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  5. J. W. Parker
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  6. R. Blumhardt
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  7. R. R. Reece
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Additional information

Grant: This research is being supported by the Department of Clinical Investigation, Brooke Army Medical Center, under work unit no. C-65-81

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Quattromani, F., Shapiro, S.D., Young, R.S. et al. Clinical heterogeneity in the tricho-dento-osseous syndrome. Hum Genet 64, 116–121 (1983). https://doi.org/10.1007/BF00327105

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  • DOI: https://doi.org/10.1007/BF00327105

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