Skip to main content
SpringerLink
Log in

Genetic linkage relationships between the Xg blood group system and two X chromosome DNA polymorphisms in families with Duchenne and Becker muscular dystrophy

  • Original Investigations
  • Published:
Human Genetics Aims and scope Submit manuscript

Summary

The existence of linkage has been investigated between the Xg blood group system, two DNA restriction fragment length polymorphisms (RFLPs) located on the short arm of the X chromosome, Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD). No linkage was found between the Xg locus and the more proximal RFLP (L1.28); close linkage between Xg and the more distal RFLP (λRC8) was also excluded. Both RFLPs show linkage with DMD but are not closely linked with each other. Analyses of 11 families with DMD and ten with BMD, informative for the Xg blood group, reinforce the conclusions of others that there is no measurable linkage between the loci for Xg and for the X-linked forms of muscular dystrophy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Adam A, Ziprkowski L, Feinstein A, Sanger R, Tippett P, Gavin J, Race RR (1969) Linkage relations of X-borne ichthyosis, to the Xg blood groups and to other markers of the X in Israelis. Ann Hum Genet 32:323–332

    Google Scholar 

  • Blyth H, Carter CO, Dubowitz V, Emery AEH, Gavin J, Johnston HA, McKusick VA, Race RR, Sanger R, Tippett P (1965) Duchenne's muscular dystrophy and the Xg blood group: a search for linkage. J Med Genet 2:157–160

    Google Scholar 

  • Clark JI, Puite RH, Marczynski R, Mann JD (1963) Evidence for the absence of detectable linkage between the genes for Duchenne muscular dystrophy and the Xg blood group. Am J Hum Genet 15:292–297

    Google Scholar 

  • Davies KE, Pearson PL, Harper PS, Murray JM, O'Brien T, Sarfarazi M, Williamson R (1983) Linkage analysis of two cloned DNA sequences flanking the Duchenne muscular dystrophy locus on short arm of the human X-chromosome. Nucleic Acids Res 11:2303–2312

    Google Scholar 

  • Emery AEH, Smith CAB, Sanger R (1969) The linkage relations of the loci for benign (Becker type) X-borne muscular dystrophy, colour blindness and the Xg blood groups. Ann Hum Genet 32:261–269

    Google Scholar 

  • Ferguson-Smith MA, Sanger R, Tippett P, Aitken DA, Boyd E (1980) A familial t(X;Y) translocation which assigns the Xg blood group locus to the region Xp 22.3→pter. Human Gene Mapping 6, Oslo conference

  • Filippi G, Macciotta A (1967) Xg blood groups in muscular dystrophy. Lancet ii:565

    Google Scholar 

  • Kingston HM, Thomas NS, Pearson PL, Sarfarazi M, Harper PS (1983) Genetic linkage between Becker muscular dystrophy and a polymorphic DNA sequence on the short arm of the X chromosome. J Med Genet 20:255–258

    Google Scholar 

  • Murray JM, Davies KE, Harper PS, Meredith L, Muller CR, Williamson R (1982) Linkage relationship of a cloned DNA sequence on the short arm of the X chromosome to Duchenne muscular dystrophy. Nature 300:69–71

    Google Scholar 

  • Ott J (1974) Estimation of the recombination fraction in, human pedigrees: efficient, computation of the likelihood for human linkage studies. Am J Hum Genet 26:588–597

    Google Scholar 

  • Porter IH Schulze J, McKusick VA (1962) Linkage between glucose-6-phosphate dehydrogenase deficiency and colour blindness. Nature 193:506

    Google Scholar 

  • Race RR, Sanger R (1975) Blood groups in man, 6th edition. Blackwell Scientific Publications

  • Tiepolo L, Zuffardi O, Fraccaro M, Di Natale D, Gargantini L, Muller CR, Ropers HH (1980) Assignment by deletion mapping of the steroid sulfatase X-linked ichthyosis locus to Xp 22.3. Hum Genet 54:205–206

    Google Scholar 

  • Went LN, DeGroot WP, Sanger R, Tippett P, Gavin J (1969) X-linked ichthyosis: linkage relationship with the Xg blood groups and other studies in a large Dutch kindred. Ann Hum Genet 32:333–346

    Google Scholar 

  • Wieacker P, Davies KE, Mevorah B, Ropers HH (1983) Linkage studies in a family with X-linked recessive ichthyosis employing a cloned DNA sequence from the distal short arm of the X chromosome. Hum Genet 63:113–116

    Google Scholar 

  • Zatz M, Itskan SB, Sanger R, Frota-Pessoa O, Saldanha PH (1974) New linkage data for the X-linked types of muscular dystrophy and G-6-PD variants, colour blindness and Xg blood groups. J Med Genet 11:321–327

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Section of Medical Genetics, Department of Medicine, Welsh National School of Medicine, Health Park, CF4 4XN, Cardiff, UK

    M. Sarfarazi, P. S. Harper, H. M. Kingston, J. M. Murray & T. O'Brien

  2. Department of Biochemistry, St. Mary's Hospital Medical School, University of London, W2 1PG, London, UK

    J. M. Murray, K. E. Davies & R. Williamson

  3. MRC Blood Group Unit, University College London, Wolfson House, Stephenson Way, NW1 2HE, London, UK

    P. Tippett & R. Sanger

Authors
  1. M. Sarfarazi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P. S. Harper
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. H. M. Kingston
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. M. Murray
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. T. O'Brien
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. K. E. Davies
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. R. Williamson
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. P. Tippett
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. R. Sanger
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sarfarazi, M., Harper, P.S., Kingston, H.M. et al. Genetic linkage relationships between the Xg blood group system and two X chromosome DNA polymorphisms in families with Duchenne and Becker muscular dystrophy. Hum Genet 65, 169–171 (1983). https://doi.org/10.1007/BF00286656

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00286656

Keywords

Search

Navigation