Summary
A rat cDNA probe for preprocarboxypeptidase A was used to follow the segregation of the human gene for carboxypeptidase A (CPA) in 49 human x mouse somatic cell hybrids using Southern filter hybridization techniques. CPA was assigned to human chromosome 7q22→qter. Similarly, the probe was used to follow the segregation of the mouse gene for carboxypeptidase A (Cpa) in 19 mouse x Chinese hamster somatic cell hybrids. Cpa was assigned to mouse chromosome 6. The gene for carboxypeptidase A forms part of a syntenic group that is conserved in man and mouse.
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Preliminary chromosomal assignments of carboxypeptidase A in man and mouse have been made in abstract (Honey et al. 1983a, b)
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Honey, N.K., Sakaguchi, A.Y., Lalley, P.A. et al. Assignment of the gene for carboxypeptidase A to human chromosome 7q22→qter and to mouse chromosome 6. Hum Genet 72, 27–31 (1986). https://doi.org/10.1007/BF00278813
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DOI: https://doi.org/10.1007/BF00278813