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Two human genes encoding zinc finger proteins, ZNF12 (KOX 3) and ZNF 26 (KOX 20), map to chromosomes 7p22-p21 and 12q24.33, respectively

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Summary

Two members of the human zinc finger Krüppel family, ZNF 12 (KOX 3) and ZNF 26 (KOX 20), have been localized by somatic cell hybrid analysis and in situ chromosomal hybridization. The presence of individual human zinc finger genes in mouse-human hybrid DNAs was correlated with the presence of specific human chromosomes or regions of chromosomes in the corresponding cell hybrids. Analysis of such mouse-human hybrid DNAs allowed the assignment of the ZNF 12 (KOX 3) gene to chromosome region 7p. The ZNF 26 (KOX 20) gene segregated with chromosome region 12q13-qter. The zinc finger genes ZNF 12 (KOX 3) and ZNF 26 (KOX 20) were localized by in situ chromosomal hybridization to human chromosome regions 7p22-21 and 12q24.33, respectively. These genes and the previously mapped ZNF 24 (KOX 17) and ZNF 29 (KOX 26) genes, are found near fragile sites.

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References

  • Arheden K, Ronne M, Mandahl N, Heim S, Kinzler KW, Vogelstein B, Mitelman F (1989) In situ hybridization localizes the human putative oncogene GLI to chromosome subbands 12q 13.3–14.1. Hum Genet 82:1–2

    Google Scholar 

  • Ashworth A, Williams BP, Buchberg AM, Goodfellow PN, Solomon E, Potter J, Willison KR (1989) Chromosomal localization of zinc finger protein genes in man and mouse. Genomics 4:323–327

    Google Scholar 

  • Bellefroid EJ, Lecocq PJ, Benhida A, Poncelet DA, Blayew A, Martial JA (1989) The human genome contains hundreds of genes encoding zinc finger proteins of the Krüppel type. DNA 8:377–387

    Google Scholar 

  • Berg JM (1988) Proposed structure for the zinc binding domain for transcription factor IIIA and related proteins. Proc Natl Acad Sci USA 85:99–102

    Google Scholar 

  • Bray P, Thiesen HJ (1990) Putting the finger on the DNA. New Biol 2:325–327

    Google Scholar 

  • Call KM, Glaser T, Ito CY, Buckler AJ, Pelletier J, Haber DA, Rose EA, Kral A, Yeger H, Lewis WH, Jones C, Housman DE (1990) Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilm's tumor locus. Cell 60:509–520

    Article  CAS  PubMed  Google Scholar 

  • Caubet JF, Mathieu-Mahul D, Bernheim A, Larsen CJ, Berger R (1985) Human protooncogene c-mos maps to 8q11. EMBO J 4:2245–2248

    Google Scholar 

  • Chavrier P, Lemiare P, Relevant O, Charnay P (1988) Characterization of a mouse multigene family that encodes zinc finger structures. Mol Cell Biol 8:1319–1326

    Google Scholar 

  • Chowdhury K, Deutsch V, Grass P (1987) A multigene family encoding several “finger” structures is present and differentially activated in mammalian genome. Cell 48:771–778

    Google Scholar 

  • Diakun GP, Fairall L, Klug A (1986) EXAFS study of the zinc-binding sites in the protein transcription factor IIIA. Nature 324:689–691

    Google Scholar 

  • Donti E, Lanfrancone L, Huebner K, Pascucci A, Venti G, Pengue G, Grignani F, Croce CM, Lania L, Pelicci PG (1990) Localization of the human HF.10 finger gene on a chromosome region (3p21–22) frequently deleted in human cancers. Hum Genet 84:391–395

    Google Scholar 

  • Engelke DR, Ng S-Y, Shastry BS, Roeder RG (1980) Specific interaction of a purified transcription factor with an internal control region of 5S RNA genes. Cell 19:717–728

    Google Scholar 

  • Feinberg AP, Vogelstein B (1983) A technique for radiolabelling DNA restriction endonuclease fragments to high specific activity. Anal Biochem 132:6–13

    CAS  PubMed  Google Scholar 

  • Gehring WJ (1987) Homeo boxes in the study of development. Science 236:1245–1252

    Google Scholar 

  • Gessler M, Thomas GH, Coullin P, Junien C, Mc Gillivray BC, Hayden M, Jaschek G, Bruns GAP (1989) A deletion map of the WAGR region on chromosome 11. Am J Hum Genet 44: 486–495

    Google Scholar 

  • Ginsberg AM, King BO, Roeder RG (1984) Xenopus 5S gene transcription factor, TFIIIA: characterization of a cDNA clone and measurement of RNA levels throughout development. Cell 39:479–489

    Google Scholar 

  • Greco A, Ittmann M, Barletta C, Basilico C, Croce CM, Cannizzaro LA, Huebner K (1989) Chromosomal localization of human genes required for G1 progression in mammalian cells. Genomics 4:240–245

    Google Scholar 

  • Harper ME, Saunders GF (1981) Localization of single copy DNA sequences on G-banded human chromosomes by in-situ hybridization. Chromosoma 83:431–439

    Google Scholar 

  • Huebner K, Ferrari AC, Delli Bovi P, Croce CM, Basilico C (1988) The FGF-related oncogene, K = FGF, maps to human chromosome region 11q13, possibly near int-2. Oncogence Res 3:263–270

    Google Scholar 

  • Joseph LJ, LeBeau MM, Jamieson GA, Acharya S, Shows TB, Rowley JD, Sukhatme VP (1988) Molecular cloning, sequencing, and mapping of EGR2, a human early growth response gene encoding a protein with “zinc-binding finger” structure. Proc Natl Acad Sci USA 85:7164–7168

    Google Scholar 

  • Kadonaga JT, Carner KR, Masiarz FR, Tjian R (1987) Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain. Cell 51:1079–1090

    Google Scholar 

  • Kongsuwan K, Webb E, Housiaux P, Adams JM (1988) Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages. EMBO J 7:2131–2138

    Google Scholar 

  • Lania L, Donti E, Panutti A, Pascucci A, Pengue G, Feliciello I, LaMantia G, Lanfrancone L, Pelicci PG (1990) cDNA isolation, expression analysis and chromosomal localization of two human zinc finger genes. Genomics 6:333–340

    Google Scholar 

  • Miller J, McLachlan AD, Klug A (1985) Repetetive zinc binding domains in the protein transcription factor IIIA from Xenopus oocytes. EMBO J 4:1604–1614

    Google Scholar 

  • Motegi T, Ochuchi M, Ohtaki C, Fujiwara K, Enomoto S, Hasegawa T, Kishi K, Hayakawa H (1985) A craniosynostosis in a boy with a del(7) (p15.3p21.3): assignment by deletion mapping of the critical segment for craniosynostosis to the mid-portion of 7p21. Hum Genet 71:160–162

    Google Scholar 

  • Müller G, Schempp W (1989) Mapping the human ZFX locus to Xp21.3 by in-situ hybridization. Hum Genet 82:82–84

    Google Scholar 

  • Nadeau JH, Birkenmeier CS, Chowdhury K, Crosby JL, Lalley PA (1990) Zinc finger protein gene complexes on mouse chromosomes 8 and 11. Genomics 8:469–476

    Google Scholar 

  • Page DC, Mosher R, Simpson EM, Fischer EMC, Mardon G, Pollack J, McGillivray B, Chapelle A de la, Brown LB (1987) The sex determining region of the human Y chromosome encodes a finger protein. Cell 51:1090–1104

    Google Scholar 

  • Panutti A, Lanfrancone L, Pascussi A, La Mantia G, Pelicci PG, Lania L (1988) Isolation of cDNA encoding finger proteins and measurements of the corresponding mRNA levels during myeloid terminal differentiation. Nucleic Acids Res 16:4227–4237

    Google Scholar 

  • Preiss A, Rosenberg VB, Kienlin A, Seifert E, Jäckle M (1985) Molecular genetics of Krüppel, a gene required for segmentation of the Drosophila embryo. Nature 313:27–32

    Google Scholar 

  • Rosenberg UB, Schröeder C, Priess A, Kienlin A, Cžote S, Riede I, Jäckle H (1986) Structural homology of the product of the Drosophila Krüppel gene with Xenopus transcription factor IIIA. Nature 319:336–339

    Google Scholar 

  • Rousseau-Merck MF, Huebner K, Berger R, Thiesen HJ (1990) Chromosomal localization of two human zinc finger protein genes, ZNF 24 (KOX 17) and ZNF 29 (KOX26) to 18q12 and 17p12-p13, respectively. Genomics (in press)

  • Ruppert JM, Kinzler KW, Wong AJ, Binger SH, Kao FT, Law ML, Seuanez HN, O'Brien SJ, Vogelstein B (1988) The Gli-Krüppel family of human genes. Mol Cell Biol 8:3104–3113

    CAS  PubMed  Google Scholar 

  • Schuh R, Aicher W, Gaul U, Cote S, Preiss A, Maier D, Seifert E, Nauber U, Schröder C, Kemler R, Jäckle H (1986) A conserved family of nuclear proteins containing structural elements of the finger protein encoded by Krüppel, a Drosophila segmentation gene. Cell 47:1025–1032

    Google Scholar 

  • Spana C, Harrison DA, Corces VC (1988) The Drosophila melangaster suppressor of hairy-wing protein binds to specific sequences of the gypsy retrotransposon. Genes Dev 2:1414–1423

    Google Scholar 

  • Stanojevic D, Hoey T, Levine M (1989) Sequence-specific DNA-binding activities of the gap proteins encoded by hunchback and Krüppel in Drosophila. Nature 341:331–335

    Google Scholar 

  • Sukhatme VP, Cao X, Chang LC, Tsai-Morris CH, Stamenkovitch D, Ferreira PCP, Cohen DR, Edwards SA, Shows TB, Curran T, LeBeau MM, Adamson D (1988) A zinc finger encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization. Cell 53:37–43

    Google Scholar 

  • Sutherland GR, Ledbetter DH (1989) Report of the committee on cytogenetic markers. (10th International Workshop on Human Gene Mapping) Cytogenet Cell Genet 51:452–458

    Google Scholar 

  • Tautz D, Lehmann R, Schnüren H, Schuh R, Seifert E, Kienlin A, Jones K, Jäckle H (1987) Finger protein of novel structure encoded by hunchback, a second member of the gap class of Drosophila segmentation genes. Nature 327:383–389

    Google Scholar 

  • Thiesen HJ (1990) Multiple genes encoding zinc finger domains are expressed in human T cells. New Biol 2:363–374

    Google Scholar 

  • Yunis JJ, Sawyer JR, Ball DW (1978) Characterization of banding pattern of metaphase G-banded chromosomes and their use in gene mapping. Cytogenet Cell Genet 22:679–683

    Google Scholar 

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Authors and Affiliations

  1. INSERM U.301 et S.D.I No. 15954 I CNRS, Institut de Génétique Moléculaire, 27, Rue Juliette Dodu, F-75010, Paris, France

    P. Seite, M. F. Rousseau-Merck & R. Berger

  2. Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, 19140, Philadelphia, PA, USA

    K. Huebner

  3. Basel Institute for Immunology, Grenzacherstrasse 487, CH-4005, Basel, Switzerland

    H. J. Thiesen

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  1. P. Seite
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  2. K. Huebner
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  3. M. F. Rousseau-Merck
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  4. R. Berger
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  5. H. J. Thiesen
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Seite, P., Huebner, K., Rousseau-Merck, M.F. et al. Two human genes encoding zinc finger proteins, ZNF12 (KOX 3) and ZNF 26 (KOX 20), map to chromosomes 7p22-p21 and 12q24.33, respectively. Hum Genet 86, 585–590 (1991). https://doi.org/10.1007/BF00201545

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  • DOI: https://doi.org/10.1007/BF00201545

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