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A multiple interval physical map of the pericentromeric region of human chromosome 10

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Abstract

Five intervals in the pericentromeric region of human chromosome 10 have been defined using a panel of somatic cell hybrids carrying portions of the chromosome. The map positions of twelve markers, consisting of four genes and eight anonymous DNA segments, have been localized by assignment to one of the five intervals. Several other markers could be placed in specific intervals by genetic linkage to assigned loci. When previously published data are incorporated, the summary map of the pericentromeric region encompasses thirty-two loci in bands 10p11.2-q11.2.

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References

  • Callen DF, Hyland VJ, Baker EG, Fratini A, Simmers RN, Mulley JC, Sutherland GR (1988) Fine mapping of gene probes and anonymous DNA fragments to the long arm of chromosome 16. Genomics 2:144–153

    Google Scholar 

  • Cervini R, Rocchi M, Di Donato S, Finocchiaro G (1991) Isolation and sub-chromosomal localization of a DNA fragment of the human choline acetyltransferase gene. Neurosci Lett 132:191–194

    Google Scholar 

  • Decker RA, Moore J, Ponder B, Weber JL (1992) Linkage mapping of human chromosome 10 microsatellite polymorphisms. Genomics 12:604–606

    Google Scholar 

  • Funk CD, Funk LB, Fitzgerald GA, Samuelsson B (1992) Characterization of human 12-lipoxygenase genes. Proc Natl Acad Sci USA 89:3962–3966

    Google Scholar 

  • Gardner E, Papi L, Easton DF, Cummings T, Jackson CE, Kaplan M, Love DR, Mole SE, Moore JK, Mulligan LM, Norum RA, Ponder MA, Reichlin S, Stall G, Telenius H, Telenius-Berg M, Tunnacliffe A, Ponder BAJ (1993) Genetic linkage studies map the multiple endocrine neoplasia type 2 loci to a small interval on chromosome 10q11.2. Hum Mol Genet 2:241–246

    Google Scholar 

  • Goodfellow PJ, Miller DL (1992) Localization of the gene for arachidonate 5-lipoxygenase. Am J Hum Genet 51 [Suppl]: A396

    Google Scholar 

  • Goodfellow PJ, Povey S, Nevanlinna HA, Goodfellow PN (1989) Assignment of the gene encoding the beta-subunit of the hman fibronectin receptor (beta-FNR) to chromosome 10p11.2. Ann Hum Genet 53:15–22

    Google Scholar 

  • Graham A, Hopkins B, Powell SJ, Danks P, Briggs I (1991) Isolation and characterisation of the human lung NK-2 receptor gene using rapid amplification of cDNA ends. Biochem Biophys Res Commun 177:8–16

    Google Scholar 

  • Howe JR, Lairmore TC, Mishra SK, Dou S, Veile, Wells SA, Donis-Keller H (1992) Improved predictive test for MEN2, using flanking dinucleotide repeats and RFLPs. Am J Hum Genet 51:1430–1442

    Google Scholar 

  • Jackson MS, Mole SE, Ponder BAJ (1992) Characterisation of a boundary between satellite III and alphoid sequences on human chromosome 10. Nucleic Acids Res 20:4781–4787

    Google Scholar 

  • Lairmore TC, Dou S, Howe JR, Chi D, Carlson K, Veile R, Mishra SK, Wells SA, Donis-Keller H (1993) A 1.5-megabase yeast artificial chromosome contig from human chromosome 10q11.2 connecting three genetic loci (RET, D10S94, and D10S102) closely linked to be MEN2A locus. Proc Natl Acad Sci USA 90:492–496

    Google Scholar 

  • Lichter JB, Wu J, Miller D, Goodfellow PJ, Kidd KK (1992) A high-resolution meiotic mapping panel for the pericentromeric region of chromosome 10. Genomics 13:607–612

    Google Scholar 

  • Maniatis T, Fritsch EF, Sambrook J (1982) Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory Press Cold Spring Harbor, NY

    Google Scholar 

  • Mathew CGP, Chin KS, Easton DF, Thorpe K, Carter C, Liou GI, Gong S-L, Bridges CDB, Haak H, Nieuwenhuijzen-Kruseman AC, Schifter S, Hansen H, Telenius H, Telenius-Berg M, Ponder BAJ (1987) A linked genetic marker for multiple endocrine neoplasia type 2A on chromosome 10. Nature 328:527–528

    Google Scholar 

  • Mathew CGP, Wakeling W, Jones E, Easton D, Fisher R, Strong C, Smith B, Chin K, Little P, Nakamura Y, Shows TB, Jones C, Goodfellow PJ, Povey S, Ponder BAJ (1990) Regional localization of polymorphic markers on chromosome 10 by physical and genetic mapping. Ann Hum Genet 54:121–129

    Google Scholar 

  • Mathew CG, Easton DF, Nakamura Y, Ponder BAJ, MEN 2A International Collaborative Group (1991) Presymptomatic screening for multiple endocrine neoplasia type 2A with linked DNA markers. Lancet 337:7–11

    Google Scholar 

  • Matsumoto T, Funk CD, Radmark O, Höög J-O, Jörnvall H, Samuelsson B (1988) Molecular cloning and amino acid sequence of human 5-lipoxygenase. Proc Natl Acad Sci USA 85:26–30

    Google Scholar 

  • Miller DL, Dill FJ, Lichter JB, Kidd KK, Goodfellow PJ (1992) Isolation and high-resolution mapping of new DNA markers from the pericentromeric region of chromosome 10. Genomics 13:601–606

    Google Scholar 

  • Mole SE, Jackson MS, Tokino T, Nakamura Y, Ponder BAJ (1993a) Assignment of fifty-four cosmid clones to five regions of chromosome 10. Genomics 15:457–458

    Google Scholar 

  • Mole SE, Mulligan LM, Healey CS, Ponder BAJ, Tunnacliffe A (1993b) Localisation of the gene for multiple endocrine neoplasia type 2A to a 480 kb region in chromosome band 10q11.2. Hum Mol Genet 2:247–252

    Google Scholar 

  • Morten JEN, Hopkins B, Powell SJ, Graham A (1991) Human NK-2 receptor gene maps to chromosome region 10q11–21. Hum Genet 88:200–203

    Google Scholar 

  • Mueller OT, Henry WM, Haley LL, Byers MG, Eddy RL, Shows TB (1986) Sialidosis and galactosialidosis: chromosomal assignment of two genes associated with neuraminidase-deficiency disorders. Proc Natl Acad Sci USA 83:1817–1821

    Google Scholar 

  • Mulligan LM, Gardner E, Telenius H, Ponder BAJ (1992) Complementary physical and genetic techniques map the vinculin (VCL) gene on chromosome 10q. Genomics 13:1347–1349

    Google Scholar 

  • Mulligan LM, Kwok JBJ, Healey CS, Esdon MJ, Eng C, Gardner E, Love DR, Mole SE, Moore JK, Papi L, Ponder MA, Telenius H, Tunnacliffe A, Ponder BAJ (1993) Germline mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A (MEN 2A). Nature 363:458–460

    Google Scholar 

  • Nakamura Y, Mathew CGP, Sobol H; Easton DF, Telenius H, Bragg T, Chin K, Clark J, Jones C, Lenoir GM, White R, Ponder BAJ (1989) Linked markers flanking the gene for multiple endocrine neoplasia type 2A. Genomics 5:199–203

    Google Scholar 

  • Norum RA, Worsham MJ, Van Dyke DL, Babu VR, Jackson CE (1988) Chromosome rearrangements localizing the chromosome 10 loci RBP3 and D10S5. Am J Hum Genet 43 [Suppl]: A154

    Google Scholar 

  • Olson M, Hood L, Cantor C, Botstein D (1989) A common language for physical mapping of the human genome. Science 245:1434–1435

    Google Scholar 

  • Ørstavik S, Sandberg M, Bérubé D, Natarajan V, Simard J, Walter U, Gagné R, Hansson V, Jahnsen T (1992) Localization of the human gene for type I cyclic GMP-dependent protein kinase to chromosome 10. Cytogenet Cell Genet 59:270–273

    Google Scholar 

  • Rothschild CB, Noll WW, Gravius TC, Schuster MK, Nutile-Mc-Nenemy N, Jones C, Bowden DW (1992) Characterization of radiation/fusion hybrids containing parts of human chromosome 10 and their use in mapping chromosome 10-specific probes. Genomics 13:25–34

    Google Scholar 

  • Rousseau-Merck MF, Tunnacliffe A, Berger R, Ponder BAJ, Thiesen HJ (1992) A cluster of expressed zinc finger protein genes in the pericentromeric region of human chromosome 10. Genomics 13:845–848

    Google Scholar 

  • Sandberg M, Natarajan V, Ronander I, Kalderon D, Walter U, Lohmann SM, Jahnsen T (1989) Molecular cloning and predicted full-length amino acid sequence of the type Iβ isozyme of cGMP-dependent protein kinase from human placenta. FEBS Lett 255:321–329

    Google Scholar 

  • Simpson NE, Myers S, Kidd JR, Jackson CE, Duncan AMV, Farrer LA, Brasch K, Castiglione C, Gend M, Gertner J, Greenberg CR, Gusella JF, Holden JJA, White BN (1987) Assignment of multiple endocrine neoplasia type 2A to chromosome 10 by linkage. Nature 328:528–530

    Google Scholar 

  • Strauss WL, Kemper RR, Jayakar P, Kong CF, Hersh LB, Hilt DC, Rabin M (1991) Human choline acetyltransferase gene maps to region 10q11-q22, 2 by in situ hybridization, Genomics 9:396–398

    Google Scholar 

  • Trask BJ, Engh G van den, Christensen M, Massa HF, Gray JW, Van Dilla M (1991) Characterization of somatic cell hybrids by bivariate flow karyotyping and fluorescence in situ hybridization. Somat Cell Mol Genet 17:117–136

    Google Scholar 

  • Tunnacliffe A, Liu L, Moore JK, Leversha MA, Jackson MS, Papi L, Ferguson-Smith MA, Thiesen H-J, Ponder BAJ (1993) Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution. Nucleic Acids Res 21:1409–1417

    Google Scholar 

  • Viegas-Pequignot E, Berrard S, Brice A, Apiou F, Mallet J (1991) Localization of a 900-bp-long fragment of the human choline acetyltransferase gene to 10q11, 2 by nonradioactive in situ hybridization. Genomics 9:210–212

    Google Scholar 

  • Weissenbach J, Gyapay G, Dib C, Vignal A, Morissette J, Millasseau P, Vaysseix G, Lathrop M (1992) A second generation linkage map of the human genome. Nature 359:794–801

    Google Scholar 

  • Wu J, Carson N, Myers S, Pakstis A, Kidd J, Castiglione C, Anderson L, Hoyle L, Genel M, Simpson N, Kidd KK (1990) The genetic defect in multiple endocrine neoplasia type 2A maps next to the centromere of chromosome 10. Am J Hum Genet 46:624–630

    Google Scholar 

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Author notes

  1. D. R. Love

    Present address: School of Biological Sciences, University of Auckland, Auckland, New Zealand

  2. S. E. Mole

    Present address: Department of Paediatrics, The Rayne Institute, University College, London, UK

Authors and Affiliations

  1. CRC Human Cancer Genetics Research Group, Department of Pathology, University of Cambridge, Cambridge, UK

    A. Tunnacliffe, M. S. Jackson, E. Gardner, D. R. Love, J. K. Moore, S. E. Mole, L. M. Mulligan & B. A. J. Ponder

  2. Zeneca Pharmaceuticals, Macclesfield, Cheshire, UK

    A. Graham

  3. Istituto Nazionale Neurologico, Milano, Italy

    G. Finocchiaro

  4. Institute of Medical Biochemistry, University of Oslo, Oslo, Norway

    S. Ørstavik

Authors
  1. A. Tunnacliffe
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  2. M. S. Jackson
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  3. E. Gardner
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  4. D. R. Love
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  5. J. K. Moore
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  6. S. E. Mole
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  7. L. M. Mulligan
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  8. A. Graham
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  9. G. Finocchiaro
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  10. S. Ørstavik
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  11. B. A. J. Ponder
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Tunnacliffe, A., Jackson, M.S., Gardner, E. et al. A multiple interval physical map of the pericentromeric region of human chromosome 10. Hum Genet 93, 313–318 (1994). https://doi.org/10.1007/BF00212029

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  • DOI: https://doi.org/10.1007/BF00212029

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