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A novel site of DNA amplification on chromosome 1p32-33 in a rhabdomyosarcoma revealed by comparative genomic hybridization

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Abstract

Cytogenetic analysis of a human embryonal rhabdomyosarcoma revealed a near-diploid karyotype with structural chromosome aberrations not involving the typical rearrangements of rhabdomyosarcomas, plus a large number of double minutes. Comparative genomic hybridization revealed a previously undescribed site of DNA amplification on the short arm of chromosome 1 (band 1p32-33).

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Authors and Affiliations

  1. Dep. of Neurosurgery, University Clinic Bldg. 91, 66421, Homburg/Saar, Germany

    Heike Steilen-Gimbel

  2. Departments of Human Genetics, Pathology, and Pediatrics, Saarland University, Homburg/ Saar, Germany

    Klaus Remberger, Norbert Graf, Wolf-Ingo Steudel, Klaus Dieter Zang & Wolfram Henn

Authors
  1. Heike Steilen-Gimbel
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  2. Klaus Remberger
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  3. Norbert Graf
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  4. Wolf-Ingo Steudel
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  5. Klaus Dieter Zang
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  6. Wolfram Henn
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Steilen-Gimbel, H., Remberger, K., Graf, N. et al. A novel site of DNA amplification on chromosome 1p32-33 in a rhabdomyosarcoma revealed by comparative genomic hybridization. Hum Genet 97, 87–90 (1996). https://doi.org/10.1007/BF00218839

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  • DOI: https://doi.org/10.1007/BF00218839

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