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Mapping the locus for familial hypertrophic cardiomyopathy to chromosome 11 in a family with a case of apical hypertrophic cardiomyopathy of the Japanese type

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Abstract

To identify the disease locus of familial hypertrophic cardiomyopathy (FHC) in a Chinese family, a genetic linkage study was performed using polymorphisms from various chromosomal regions. This family has eight affected members, including a case with typical features of apical hypertrophic cardiomyopathy of the Japanese type. The results revealed significant evidence of linkage of polymorphisms on chromosome 11p13-q13 and FHC in this family with a maximal lod score of 3.38 atθ = 0.00. Our data suggest that the locus responsible for FHC in this family maps to chromosome 11 and that the molecular basis of FHC in the case of apical hypertrophic cardiomyopathy of the Japanese type might be similar to that of other affected members in the same family. Further studies are needed to elucidate the whole spectrum of the genetic basis of apical hypertrophic cardiomyopathy of the Japanese type.

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Authors and Affiliations

  1. Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, Republic of China

    Yu-Lin Ko, Peiliang Kuan & Wen-Pin Lien

  2. Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, Republic of China

    Jin-Jer Chen, Tang-K. Tang, Ming-Sheng Teng, Sheng-Yu Lin & Cheng-Wen Wu

  3. Department of Clinical Chemistry and Medicine, Centre for Cardiovascular Research, University of Toronto, Toronto, Canada

    Choong-Chin Liew

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  1. Yu-Lin Ko
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  2. Jin-Jer Chen
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  3. Tang-K. Tang
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  4. Ming-Sheng Teng
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  5. Sheng-Yu Lin
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  6. Peiliang Kuan
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  7. Cheng-Wen Wu
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  8. Wen-Pin Lien
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  9. Choong-Chin Liew
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Mailing address: Chang Gung Memorial Hospital, 199, Tung Hwa North Road, Taipei, Taiwan 105, Republic of China

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Ko, YL., Chen, JJ., Tang, TK. et al. Mapping the locus for familial hypertrophic cardiomyopathy to chromosome 11 in a family with a case of apical hypertrophic cardiomyopathy of the Japanese type. Hum Genet 97, 457–461 (1996). https://doi.org/10.1007/BF02267066

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  • DOI: https://doi.org/10.1007/BF02267066

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