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Biosynthesis of the basal lamina as a result of interaction between thyroid and mesenchymal cells in culture

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Summary

Porcine thyroid cells were cultured alone or in mixed cultures with mesenchymal cells. The formation of a basal lamina in vitro was investigated ultrastructurally. Follicular reassociation of thyroid cells occurred in both types of culture; however, it was followed by formation of the basal lamina only when mesenchymal cells were present. The present findings suggest an epithelial origin of the basal lamina resulting from an interaction with mesenchymal cells.

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Authors and Affiliations

  1. Faculté de Médecine, Laboratoire d'Histologie I and ERA-CNRS n∘ 322, Marseille, France

    Christian Alquier & Marc Michel-Béchet

  2. Faculté de Médecine, Laboratoire de Biochimie Médicale and U 38 INSERM, Marseille, France

    Guy Fayet & Sonia Hovsepian

Authors
  1. Christian Alquier
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  2. Guy Fayet
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  3. Sonia Hovsepian
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  4. Marc Michel-Béchet
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Additional information

The authors wish to thank Mrs. J. Bottini for skillful preparation of the manuscript. This study was supported by the CNRS-ERA n∘ 322 and by INSERM-CRL n∘ 75 50394

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Alquier, C., Fayet, G., Hovsepian, S. et al. Biosynthesis of the basal lamina as a result of interaction between thyroid and mesenchymal cells in culture. Cell Tissue Res. 200, 69–81 (1979). https://doi.org/10.1007/BF00236888

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