Summary
The structure of glandular cells in the anterior lobe of the rabbit prostate was reinvestigated, especially after fixation by vascular perfusion with glutaraldehyde. The lumina of the gland contain abundant globules of an amorphous material surrounded by a membrane. A few dense bodies and scattered globules with internal vesicles also occur. These luminar contents obviously correspond to the particles observed in the semen of rabbits. Strong evidence was found for the formation of the globules by an apocrine secretory process. Material similar to the contents of the luminar globules accumulates in the cell apex together with vesicles, probably of Golgi origin, but without any other organelles. Protrusions from the cell surface contain similar material, but the vesicles generally disappear before the forming globule is finally pinched off from the cell surface.
The characteristic feature of the secretory cell are the paucity of endoplasmic reticulum and the large amounts of ribosomes. This is interpreted as a specialization of the cell for the production of secretory protein that is not segregated within membranes until it is discharged from the cell by apocrine secretion.
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References
Brandes, D.: The fine structure and histochemistry of prostatic glands in relation to sex hormones. Int. Rev. Cytol. 20, 207–276 (1966)
Dahl, E., Kjaerheim, Å., Tveter, K. J.: The ultrastructure of the accessory sex organs of the male rat. 1. Normal structure. Z. Zellforsch. 137, 345–359 (1973)
Dauwalder, M., Whaley, W. G., Kephart, J. E.: Functional aspects of the Golgi apparatus. Sub.-Cell. Biochem. 1, 225–275 (1972)
Droz, B., Pisam, M., Chrétien, M.: Morphological aspects of protein synthesis. Acta endocr. (Kbh.) 180, 13–30 (1973)
Helminen, H. J., Ericsson, J. L. E.: On the mechanism of lysosomal enzyme secretion. Electron microscopic and histochemical studies on the epithelial cells of the rat's ventral prostate lobe. J. Ultrastruct. Res. 33, 528–549 (1970)
Linzell, J. L., Peaker, M.: Mechanism of milk secretion. Physiol. Rev. 51, 564–597 (1971)
Mann, T.: Biochemistry of semen and of the male reproductive tract. London: Methuen & Co. 1964
Metz, C. B., Hinsch, G. W., Anika, J. L.: Ultrastructure and antigens of particles from rabbit semen. J. Reprod. Fertil. 17, 195–198 (1968)
Nicander, L.: On the morphological evidence of secretion and absorption in the epididymis. Morph. Aspects Androl. 1, 121–124 (1970)
Nicander, L., Larsson, M., Plöen, L.: True apocrine secretion in the anterior prostate gland of the rabbit. J. Ultrastruct. Res. 44, 443 (1973)
Plöen, L.: Observations on ram seminal vesicles with special reference to the secretory process. Cell Tiss. Res. in press (1974)
Schantz, B.: On the ultrastructure of carbohydrate secreting glands: 1. The anterior lobe of the rabbit prostate. Acta anat. (Basel) 56, 35–53 (1964a)
Schantz, B.: Electron microscopy observations on the posterior lobe of the prostate gland in rabbits. Acta anat. (Basel) 56, 54–69 (1964b)
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Nicander, L., Plöen, L. & Larsson, M. Specific apocrine secretion in the anterior lobe of the prostate gland of rabbits. Cell Tissue Res. 151, 69–77 (1974). https://doi.org/10.1007/BF00222035
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DOI: https://doi.org/10.1007/BF00222035