Summary
Vinblastine treatment blocks corticosterone release from rat adrenal zona fasciculata without impairing hormone synthesis, and induces the formation of acid phosphatase-positive granular clumps at the juxta-sinusoidal pole of the cells. Autoradiography shows that ACTH administration to vinblastine-treated animals mobilizes the 3H-cholesterol stored in the lipid droplets and leads to a noticeable labelling of the granular clumps. The possible significance of these granules is discussed.
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Nussdorfer, G.G., Mazzocchi, G., Neri, G. et al. Investigations into the mechanism of hormone release by rat adrenocortical cells. Cell Tissue Res. 189, 403–407 (1978). https://doi.org/10.1007/BF00209129
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DOI: https://doi.org/10.1007/BF00209129