Summary
The filum terminale, or terminal portion of the spinal cord, was studied in normal adult frogs (Rana pipiens) by means of light and electron microscopy. Astroglial cells are the predominant elements in this region. The rostral portion of the filum terminale consists mainly of (1) a peripheral dense ring of myelinated and some unmyelinated nerve fibers, and processes of astrocytes terminating at the subpial space; (2) an intermediate zone, in which astrocytes are the main cellular elements in addition to a few degenerated neurons; and (3) a central region where the central canal is lined by dark and light ependymal cells. In the caudal portion of the filum terminale, the amount of neuropil is greatly reduced. This region is formed mainly by astrocytic glial cells and very few neuronal elements. The central canal in the caudal portion is located ventrally and contains a lining consisting almost exclusively of dark ependymal cells.
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References
Brightman, M.W., Palay, S.L.: The fine structure of ependyma in the brain of the rat. J. Cell Biol. 19, 415–439 (1963)
Glusman, S., Pacheco, M., González, A., Haber, B.: The filum terminale of the frog spinal cord, a non transformed glial preparation: I. Morphology and uptake of γ-aminobutyric acid. Brain Res. 1978. In press
Harmeier, J.W.: The normal histology of the intradural filum terminale. Arch. Neurol. 29, 308–316 (1933)
Hirano, A., Zimmerman, H.M.: Some new cytological observations of the normal rat ependymal cell. Anat. Rec. 158, 293–302 (1967)
Klinkerfuss, G.H.: An electron microscopic study of the ependyma and subependymal glia of the lateral ventricle of the cat. Am. J. Anat. 115, 71–100 (1964)
Kunitomo, K.: The development and reduction of the tail and of the caudal end of the spinal cord. Contrib. Embryol. 8, 161, 1918. Cited in Harmeier, J.W.: The normal histology of the intradural filum terminale. Arch. Neurol. 29, 308–316 (1933)
Oksche, A.: The subcommissural organ. J. Neur.-Visc. Rel. Suppl. IX, 111–139 (1969)
Peters, A., Palay, S.L., Webster, H. de F.: The Fine Structure of the Nervous System. New York: Harper & Row, Publishers, 1970
Ralston, H.J.: The organization of the substantia gelatinosa in the cat lumbosacral spinal cord. Z. Zellforsch, 67, 1–23 (1965)
Reynolds, E.S.: The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. J. Cell Biol. 17, 208 (1963)
Rhodin, J.A.G.: Histology. New York: Oxford University Press, 1974
Silver, M.L.: The glial elements of the spinal cord of the frog. J. Comp. Neurol. 77, 41–47 (1942)
Stensaas, L.J., Stensaas, S.S.: Astrocytic neuroglial cells, oligodendrocytes and microgliacytes in the spinal cord of the toad. Electron microscopy. Z. Zellforsch. 86, 184–213 (1968)
Streeter, G.L.: Factors involved in the formation of the filum terminale. Am. J. Anat. 25, 1 (1919). Cited in: Harmeier, J.W.: The normal histology of the intradural filum terminale. Arch. Neurol. 29, 308–316 (1933)
Tennyson, V.A., Pappas, G.D.: An electron microscope study of ependymal cells of the fetal, early postnatal and adult rabbit. Z. Zellforsch. 56, 595–618 (1962)
Tourneux, F.: Sur la structure et sur le développement du fil terminal de la moelle chez l'homme. Compt. Rend. Soc. Biol. 44, 340 (1892) Cited in: Harmeier, J.W.: The normal histology of the intradural filum terminale. Arch. Neurol. 29, 308–316 (1933)
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González-Robles, A., Glusman, S. The filum terminale of the frog spinal cord. Cell Tissue Res. 199, 519–528 (1979). https://doi.org/10.1007/BF00236087
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DOI: https://doi.org/10.1007/BF00236087