Summary
Injection of disulfiram, a specific inhibitor of noradrenaline synthesis, evokes changes in two different types of neurons in the brain of Galleria mellonella: neurones containing dense-core vesicles (60–80 nm) and peptidergic cells containing 180–200 nm neurosecretory granules.
The lowering of the electron density of the dense-core vesicles of 60–80 nm seems to be directly connected with disulfiram administration, while the decrease of the amount of neurosecretory material in the neurosecretory cells of type I seems to be a secondary effect of the drug injection. The participation of noradrenaline in the regulation of the secretory activity of type I peptidergic neurosecretory cells of the pars intercerebralis is postulated.
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The author is grateful to Prof. S. Niemierko for her critical review of the manuscript and to the engineering staff of the Electron Microscopy Laboratory for its technical help
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Wartoń, S. Effect of disulfiram on the ultrastructure of the peptidergic and aminergic cells in the pars intercerebralis of Galleria mellonella (Lepidoptera). Cell Tissue Res. 215, 417–424 (1981). https://doi.org/10.1007/BF00239124
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DOI: https://doi.org/10.1007/BF00239124