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Destruction of Hassall's corpuscles by macrophages in the sheep thymus

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Summary

The dissolution of Hassall's corpuscles by macrophages has been demonstrated in the sheep thymus. The findings indicate that enlarged Hassall's corpuscles are rapidly broken down by macrophages at the end of gestation or immediately after birth and replaced by newly formed corpuscles, and that these cyclic changes in Hassall's corpuscles persist, under normal physiological conditions, throughout life.

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Author notes

  1. M. Kotani

    Present address: Department of Anatomy, Faculty of Medicine, University of Kumamoto, Honjo, 860, Kumamoto, Japan

  2. T. Fukumoto

    Present address: Department of Anatomy, Hamamatsu Medical College, Hamamatsu, Japan

  3. M. R. Brandon

    Present address: MRC Cellular Immunology Unit, Sir William Dunn School of Pathology, Oxford University, Oxford, England

Authors and Affiliations

  1. Department of Immunology, John Curtin School of Medical Research, Australian National University, Canberra, Australia

    M. Kotani, T. Fukumoto & M. R. Brandon

Authors
  1. M. Kotani
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  2. T. Fukumoto
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  3. M. R. Brandon
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Kotani, M., Fukumoto, T. & Brandon, M.R. Destruction of Hassall's corpuscles by macrophages in the sheep thymus. Cell Tissue Res. 217, 49–54 (1981). https://doi.org/10.1007/BF00233825

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  • DOI: https://doi.org/10.1007/BF00233825

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