Summary
Autoradiographic studies showed that in the rat hippocampus “microglia-like reactive cells” (MRC) and astrocytes are capable of proliferation in response to kainic acid (KA)-induced lesions. A marked increase in the number of labeled MRC was observed during the first four days after the induction of the KA-lesion. A proliferative response of astrocytes occurred at two days after the KA-lesion. After the induction of a KA-lesion brain macrophages and oligodendrocytes were only slightly labeled with 3H-thymidine. It appears likely that MRC is the main cellular element responding to this type of lesion.
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This work was supported by a grant (No. 437002) from the Ministry of Education, Science and Culture, Japan
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Murabe, Y., Ibata, Y. & Sano, Y. Morphological studies on neuroglia. Cell Tissue Res. 222, 223–226 (1982). https://doi.org/10.1007/BF00218302
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DOI: https://doi.org/10.1007/BF00218302