Summary
In the renal juxtaglomerular region of newborn sheep, it was found that glomerular peripolar cells and their granules were very much larger than those found in fetal lambs or adult sheep. Similar peripolar cell hypertrophy was triggered in fetal lambs treated in utero with intraperitoneal injections of dexamethasone. Ultrastructurally, granules of peripolar cells from newborn lambs resembled closely the enlarged zymogen granules described in the pancreas of newborn rats. Such peripolar cell hypertrophy may reflect a functional adaptation of the kidney to immediate postnatal life.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Alcorn D, Adamson TM, Lambert TF, Maloney JE, Ritchie BC, Robinson PM (1977) Morphological effects of chronic tracheal ligation and drainage in the fetal lamb lung. J Anat 123:649–660
Avery ME (1975) Pharmacological approaches to the acceleration of fetal lung maturation. Br Med Bull 31:13–17
Ballard PL (1979) Glucocorticoids and differentiation. In: Baxter JD, Rousseau GG (eds) Glucocorticoid hormone action. Springer, Berlin, pp 493–515
Cook WF (1971) Cellular localization of renin. In: Fisher JW (ed) Kidney hormones. Academic Press, New York, pp 117–128
Ermak TH, Rothman SS (1980) Large decrease in zymogen granule size in the postnatal pancreas. J Ultrastruct Res 70:242–256
Hanner RH, Ryan GB (1980) Ultrastructure of the renal juxtaglomerular complex and peripolar cells in the axolotl (Ambystoma mexicanum) and toad (Bufo marinus). J Anat 130:445–455
Hill PA, Coghlan JP, Scoggins BA, Ryan GB Ultrastructural changes in the sheep renal juxtaglomerular apparatus in response to sodium depletion or loading. Pathology (in press)
Kleinman LI (1978) The kidney. In: Stave U (ed) Perinatal physiology. Plenum Medical Book Co, New York and London, pp 589–616
Latta H (1973) Ultrastructure of the glomerulus and juxtaglomerular apparatus. In: Orloff J, Berliner RW (eds) Handbook of physiology, section 8, renal physiology. American Physiological Society, Washington, pp 1–29
Lendrum AC, Fraser DS, Slidders W, Henderson R (1962) Studies on the character and staining of fibrin. J Clin Pathol 15:401–413
Liggins GC (1976) Adrenocortical-related maturational events in the fetus. Am J Obstet Gynecol 126:931–939
Mitchell GM, Stratford BF, Ryan GB (1982) Morphogenesis of the renal juxtaglomerular apparatus and peripolar cells in the sheep. Cell Tissue Res 222:101–111
Moog F (1971) Corticoids and enzyme maturation of the intestinal surface: alkaline phosphatase, leucyl naphtylamidase and sucrose. In: Hamburgh M, Barrington EJW (eds) Hormones in development. Appleton-Century-Crofts, New York, pp 143–160
Moscona AA (1971) Control mechanisms in hormonal induction of glutamine synthetase in the embryonic neural retina. In: Hamburgh M, Barrington EJW (eds) Hormones in development. Appleton-Century-Crofts, New York, pp 169–190
Pipkin FB, Kirkpatrick SML, Lumbers ER, Mott JC (1974) Renin and angiotensin-like levels in foetal, new-born and adult sheep. J Physiol 241:575–588
Robillard JE, Ramberg E, Sessions C, Consamus B, Van Orden D, Weissmann D, Smith FG Jr (1980) Role of aldosterone on renal sodium and potassium excretion during fetal life and newborn period. Dev Pharmacol Ther 1:201–216
Ryan GB, Coghlan JP, Scoggins BA (1979) The granulated peripolar epithelial cell: a potential secretory component of the renal juxtaglomerular complex. Nature 227:655–656
Ryan GB, Alcorn D, Coghlan JP, Hill PA, Jacobs R (1982) Ultrastructural morphology of granule release from juxtaglomerular myoepithelioid and peripolar cells. Kidney Int 22:S3-S8
Siegel SR, Fisher DA (1977) The renin-angiotensin-aldosterone system in the newborn lamb: response to furosemide. Pediat Res 11:837–839
Spitzer A (1982) The role of the kidney in sodium homeostasis during maturation. Kidney Int 21:539–545
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Alcorn, D., Cheshire, G.R., Coghlan, J.P. et al. Peripolar cell hypertrophy in the renal juxtaglomerular region of newborn sheep. Cell Tissue Res. 236, 197–202 (1984). https://doi.org/10.1007/BF00216531
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00216531