Summary
The proliferation of gonadotropes in the anterior pituitary of the castrated male rat was examined immunohistochemically after colchicine treatment. The results show a more than 10-fold increase in mitotic frequency in gonadotropes 1 or 2 weeks after castration, as compared with controls. This result explains the increase in the population of immunoreactive LH cells in castrated male rats. The gonadotropes decreased significantly 1 month after castration. The mitotic activity of gonadotropes was almost completely suppressed in castrates implanted with a silastic tube filled with testosterone.
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Inoue, K., Tanaka, S. & Kurosumi, K. Mitotic activity of gonadotropes in the anterior pituitary of the castrated male rat. Cell Tissue Res. 240, 271–276 (1985). https://doi.org/10.1007/BF00222334
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DOI: https://doi.org/10.1007/BF00222334