Riassunto
La presente indagine sulla ultrastruttura del rene di hamsters cinesi diabetici ha fatto rilevare fini lesioni glomerulari, consistenti in ispessimento non omogeneo delle membrane basali dei vasi capillari, alterazioni delle cellule del mesangio, dilatazione irregolare delle anse vascolari. A carico della parte tubulare, accumulo di glicogeno nel citoplasma delle cellule del tratto distale e del tubulo collettore; presenza di glicogeno nel nucleo negli animali con diabete grave e chetosi.
Résumé
Cette enquête sur l'ultra-structure du rein de hamsters chinois atteints de diabète a permis de relever des lésions glomérulaires légères, consistant en un épaississement non-homogène des membranes basales des vaisseux capillaires, des altérations de cellules de la mésange, une dilatation irrégulière des anses vasculaires. Sur la partie tubulaire, une accumulation de glycogène dans le cytoplasme des cellules de la partie distale et du tube collecteur ainsi que la présence de glycogène dans le noyau des animaux atteints d'un grave diabète et de kétose.
Resumen
La presente investigación sobre la ultraestructura del riñón del hamster chino diabético, ha dado la posibilidad de poner en evidencia sutiles lesiones glomerulares, consistentes en el engrosamiento no homogéneo de las membranas basales de los vasos capilares, en alteraciones de las células del mesangio, en la dilatación irregular de las ansas; y, a cargo de la parte tubular, en una acumulación de glicógeno en el citoplasma de las células del tramo distal y del túbulo colector y en la presencia de glicógeno en el núcleo de los animales con diabetes grave y quetosis.
Zusammenfassung
Die vorliegende Studie über die Ultrastruktur der Niere bei diabetischen chinesichen Hamstern hat Veränderungen der Glomeruli gezeigt und zwar ungleichmässige Verdickung der Basalmembran der Kapillargefässe, Veränderungen an den Zellen des Mesangiums, unregelmässige Verdickung der Gefäßschlingen. Im distalen Teil der Tubuli contorti und in den Sammelröhren fanden sich Glykogenhäufungen im Zytoplasma; bei Tieren mit schwerem Diabetes und Ketose wurde das Glykogen auch im Zellkern vorgefunden.
Summary
This study of the ultrastructure of the kidney of diabetic Chinese hamsters revealed fine glomerular lesions, namely: irregular thickening of the basement membranes of the capillary vessels, mesangial cell changes and irregular dilatation of the vascular loops. Glycogen accumulation was found in the cytoplasm of the cells of the distal convoluted tubule and of the collecting tubule. Glycogen was present in the nucleus in the animals with severe diabetes and ketosis.
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Conforti, A. Ultrastruttura del rene nel diabete spontaneo dell'hamster cinese (cricetulus griseus). Acta diabet. lat 9, 655–687 (1972). https://doi.org/10.1007/BF01564578
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DOI: https://doi.org/10.1007/BF01564578