Abstract
The activity of biapenem was compared with that of imipenem and cefotaxime against 108 strains of β-lactamase producingEnterobacteriaceae. Biapenem and imipenem were very active, inhibiting 90 % of the strains at a concentration of 0.5 µg/ml. Both carbapenems were very active against plasmidic β-lactamase producers, with MIC90s below 1 µg/ml. However, the MIC90 of biapenem for cephalosporinase producers was 1 µg/ml. Against strains producing extended-spectrum β-lactamases, biapenem exhibited better activity against TEM-type producers (MIC90 0.25 µg/ml) than against SHV-type producers (MIC90 0.5 µg/ml). Overall, the in vitro antibacterial activity of biapenem is similar to that of imipenem.
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Alonso, R., Fdez-Aranguiz, A., Colom, K. et al. In vitro activity of biapenem against beta-lactamase producingEnterobacteriaceae . Eur. J. Clin. Microbiol. Infect. Dis. 13, 820–822 (1994). https://doi.org/10.1007/BF02111342
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DOI: https://doi.org/10.1007/BF02111342