Skip to main content

Advertisement

SpringerLink
Log in

Prevalence of antibiotic resistance among clinical isolates of methicillin-resistant staphylococci

  • Notes
  • Published:
European Journal of Clinical Microbiology and Infectious Diseases Aims and scope Submit manuscript

Abstract

The prevalence of methicillin-resistant and multiply antibiotic-resistant staphylococci causing infections in hospitalized patients was studied over a two-year period. Among 122 clinically significant staphylococci, the prevalence of methicillin resistance was 66 %, with a higher prevalence ofStaphyloccus haemolyticus (85 %) andStaphylococcus epidermidis (83 %) observed than ofStaphylococcus aureus (49 %). Multiple antibiotic resistance was observed more frequently among coagulase-negative staphylococci (52 to 70 %) than amongStaphylococcus aureus (17 %). All strains of methicillin-resistantStaphylococcus aureus were susceptible to glycopeptide antibiotics and to trimethoprim-sulfamethoxazole, whereas approximately 50 % of coagulase-negative staphylococci exhibited either moderate susceptibility or resistance to teicoplanin. For these latter strains, vancomycin remains the agent of choice, whereas teicoplanin cannot be recommended unless its efficacy is established by MIC determination.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Mulligan ML, Murray-Leisure KA, Ribner BS, Standiford HC, John JF, Korvick JA, Kauffman CA, Yu VL Methicillin-resistantStaphylococcus aureus: a consensus review of the microbiology, pathogenesis, and epidemiology with implications for prevention and management. American Journal of Medicine 1993, 94: 313–328.

    Article  PubMed  Google Scholar 

  2. Keane CT, Cafferkey MT Re-emergence of methicillin resistantStaphylococcus aureus causing infection. Journal of Infection 1984, 9: 6–16.

    PubMed  Google Scholar 

  3. Brumfitt W, Hamilton-Miller J Methicillin-resistantStaphylococcus aureus. New England Journal of Medicine 1989, 320: 1188–1195.

    PubMed  Google Scholar 

  4. Davies AJ, Stone JW Current problems of chemotherapy of infections with coagulase-negative staphylococci. European Journal of Clinical Microbiology 1986, 19: 277–281.

    Google Scholar 

  5. Arioli V, Pallanza R Teicoplanin-resistant coagulase-negative staphylococci. Lancet 1981, i: 39.

    Google Scholar 

  6. Schwalbe RS, Stapleton JT, Gilligan PH Emergence of vancomycin resistance in coagulase-negative staphylococci. New England Journal of Medicine 1987, 316: 927–931.

    PubMed  Google Scholar 

  7. National Committee for Clinical Laboratory Standards Performance standards for antimicrobial disk susceptibility tests. Approved standard M2-A4. NCCLS, Villanova, PA, 1990.

    Google Scholar 

  8. National Committee for Clinical Laboratory Standards Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Approved standard M7-A2. NCCLS, Villanova, PA, 1990.

    Google Scholar 

  9. National Committee for Clinical Laboratory Standards Informational supplement M100-S3. NCCLS, Villanova, PA, 1991.

    Google Scholar 

  10. Bannerman TL, Wadiak DL, Kloos WE Susceptibility ofStaphylococcus species and subspecies to teicoplanin. Antimicrobial Agents and Chemotherapy 1991, 35: 1919–1922.

    PubMed  Google Scholar 

  11. Low DE, McGeer A, Poon R Activities of daptomycin and teicoplanin againstStaphylococcus haemolyticus andStaphylococcus epidermidis, including evaluation of susceptibility testing recommendations. Antimicrobial Agents and Chemotherapy 1989, 33: 585–588.

    PubMed  Google Scholar 

  12. Chomarat M, Espinouse D, Flandrois JP Coagulasenegative staphylococci emerging during teicoplanin therapy and problems in the determination of their sensitivity. Journal of Antimicrobial Chemotherapy 1991, 27: 475–480.

    PubMed  Google Scholar 

  13. Kaatz GW, Seo SM, Dorman JN, Lerner SA Emergence of teicoplanin resistance during therapy ofStaphylococcus aureus endocarditis. Journal of Infectious Diseases 1990, 162: 103–108.

    PubMed  Google Scholar 

  14. Biavasco F, Giovanetti E, Montanari MP, Lupidi R, Varaldo PE Development of in-vitro resistance to glycopeptide antibiotics: assessment in staphylococci of different species. Journal of Antimicrobial Chemotherapy 1991, 27: 71–79.

    PubMed  Google Scholar 

  15. Shalit I, Berger SA, Gorea A, Frimerman H Widespread quinolone resistance among methicillin-resistantStaphylococcus aureus isolates in a general hospital. Antimicrobial Agents and Chemotherapy 1989, 33: 593–594.

    PubMed  Google Scholar 

  16. Raviglione MC, Boyle JF, Mariuz P, Pablos-Mendez A, Cortes H, Merlo A Ciprofloxacin-resistant methicillin-resistantStaphylococcus aureus in an acute-care hospital. Antimicrobial Agents and Chemotherapy 1990, 34: 2050–2054.

    PubMed  Google Scholar 

  17. Froggatt JW, Johnston JL, Galetto DW, Archer GL Antimicrobial resistance in nosocomial isolates ofStaphylococcus haemolyticus. Antimicrobial Agents and Chemotherapy 1989, 33: 460–466.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Medical Therapy, Faculty of Medicine, Second University of Naples, Via Cotugno 1 (c/o Ospedale Gesù e Maria), 80135, Naples, Italy

    M. -F. Tripodi, V. Attanasio, L. E. Adinolfi, R. Utili & G. Ruggiero

  2. Institute of Vascular Surgery, Second University of Naples, Via Cotugno 1 (c/o Ospedale Gesù e Maria), 80135, Naples, Italy

    A. Florio

  3. Service of Microbiology, Hospital V. Monaldi, Naples, Italy

    P. Cione & S. Cuccurullo

Authors
  1. M. -F. Tripodi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. Attanasio
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. L. E. Adinolfi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. Florio
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. P. Cione
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. S. Cuccurullo
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. R. Utili
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. G. Ruggiero
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tripodi, M.F., Attanasio, V., Adinolfi, L.E. et al. Prevalence of antibiotic resistance among clinical isolates of methicillin-resistant staphylococci. Eur. J. Clin. Microbiol. Infect. Dis. 13, 148–152 (1994). https://doi.org/10.1007/BF01982189

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01982189

Keywords

Search

Navigation