Abstract
The ability of imipenem and meropenem in subinhibitory concentrations to influence the results of disk diffusion susceptibility tests was assessed. Selection of stably derepressed mutants resistant to beta-lactam antibiotics other than carbapenems was also investigated. Beta-lactams were shown to be subject to carbapenem-mediated antagonism in the disk diffusion test. On the other hand in vitro selection of stably derepressed mutants resistant to other beta-lactams could not be demonstrated.
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Giacometti, A., Siquini, F.M., Cirioni, O. et al. Imipenem and meropenem induced resistance to beta-lactam antibiotics inPseudomonas aeruginosa . Eur. J. Clin. Microbiol. Infect. Dis. 13, 315–318 (1994). https://doi.org/10.1007/BF01974609
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DOI: https://doi.org/10.1007/BF01974609