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Prevalence ofChlamydia trachomatis infection in a population of asymptomatic women in a screening program for cervical cancer

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Abstract

The prevalence ofChlamydia trachomatis infection in a population of women with no symptoms of sexually transmitted disease was investigated. These women, aged 35–55 years, participated in a screening program for cervical cancer. With the use of a direct immunofluorescence method, 109 out of 2,470 smears tested were positive forChlamydia trachomatis, indicating an overall prevalence of 4.4%. No changes in prevalence were found when five-year cohorts of this group were analyzed, indicating that age-dependent changes or epidemiological factors do not result in a different (decreased) prevalence over the ages 35 to 55 years. The prevalence ofTrichomonas vaginalis and fungi, as detected by cytological screening, was lower than that observed forChlamydia trachomatis: 3.1 and 2.1%, respectively. Of the 109 smears positive forChlamydia trachomatis, 90 showed cervical cells with reactive changes (out of 1,490 smears with PAP II), whereas no cytological changes were found in 15 cases (out of 884 smears with PAP I). Changes suggestive of mild or moderate dysplasia were found in only four cases (out of 93 smears with PAP III). The results indicate thatChlamydia trachomatis is associated with reactive changes of endocervical cells and raise serious questions about whether prevention of possible secondary effects such as infertility and pelvic inflammatory disease can be achieved by a combined screening program for cervical cancer andChlamydia trachomatis.

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References

  1. Thompson, R. C., Washington, A. E.: Epidemiology of sexually transmittedChlamydia trachomatis infection. Epidemiologic Reviews 1983, 5: 96–113.

    Google Scholar 

  2. Stamm, W. E., Holmes, K. K.:Chlamydia trachomatis infections in the adult. In: Holmes, K. K., Mårdh, P. A., Sparling, P. F., Weisner, P. J. (ed.): Sexually transmitted diseases. McGraw Hill, New York, 1984, p. 258–269.

    Google Scholar 

  3. Brunham, R. C., MacLean, I. W., Binns, B., Peeling, R. W.:Chlamydia trachomatis: its role in tubal infertility. Journal of Infectious Diseases 1985, 152: 1275–1282.

    Google Scholar 

  4. Møller, R. R., Kasperen, P., Kristiansen, F. V., Mårdh, P. A.:Chlamydia trachomatis in the upper female genital tract with negative cervical culture. Lancet 1986, ii: 390.

    Google Scholar 

  5. Kiviat, B. V., Paavonen, J. A., Brochway, J. K., Critchlow, C. W., Brunham, R. C., Stevens, C. E., Stamm, W. E., Kuo, C. C., DeRouen, T., Holmes, K. K.: Cytologic manifestations of cervical and vaginal infections. I. Epithelial and inflammatory cellular changes. Journal of the American Medical Association 1985, 253: 989–996.

    Google Scholar 

  6. Harnekar, A. B., Leiman, G., Markowitz, S.: Cytologically detected chlamydial changes and progression of cervical intraepithelial neoplasias. A retrospective case-control study. Acta Cytologica 1985, 29: 661–664.

    Google Scholar 

  7. Vooys, G. P.: De advisering bij afwijkende bevindingen van cytologisch onderzoek bij de cervix uteri. Nederlands Tijdschrift voor Geneeskunde 1987, 131: 1662–1663.

    Google Scholar 

  8. Tam, M. R., Stamm, W. E., Handsfield, H. H., Nowinski, R. C.: Culture-independent diagnosis ofChlamydia trachomatis using monoclonal antibodies. New England Journal of Medicine 1984, 310: 1146–1150.

    Google Scholar 

  9. Lindner, L. E., Geerling, S., Nettum, J. A., Miller, S. L., Altman, K. H., Wechter, S. R.: Identification of chlamydia in cervical smears by immunofluorescence: technique, sensitivity and specificity. American Journal of Clinical Pathology 1986, 85: 180–185.

    Google Scholar 

  10. Stamm, W. E., Tam, M., Koester, M., Cles, L.: Detection ofChlamydia trachomatis inclusions in McCoy cell cultures with fluorescein conjugated monoclonal antibodies. Journal of Clinical Microbiology 1983, 17: 666–668.

    Google Scholar 

  11. Tjam, K. H., van Eijk, R. V. W., Heijst B. Y. M. van, Tideman, G. J., Joost, Th. van, Stolz, E., Michel, M. F.: Evaluation of the direct fluorescent antibody test for diagnosis of chlamydial infections. European Journal of Clinical Microbiology 1985, 4: 548–552.

    Google Scholar 

  12. Westrom, L., Mårdh, P. A.: Genital chlamydial infections in the female. In: Mårdh, P. A., Holmes, K. K., Oriel, J. D., Piot, P., Schachter, J. (ed.): Chlamydial infections. Elsevier Biochemical Press, Amsterdam, 1982, p. 121–139.

    Google Scholar 

  13. Winkler, B., Crum, C. P.:Chlamydia trachomatis infections of the female genital tract. Pathogenic and clinicopathologic correlations. Pathology Annual 1987, 21 (1): 193–223.

    Google Scholar 

  14. Ridgway, G. L., Oriel, J. D., Mumtaz, G., Mellars, B.: Comparison of methods for detectingChlamydia trachomatis. Journal of Clinical Pathology 1986, 39: 232–233.

    Google Scholar 

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Meijer, C.J.L.M., Calame, J.J., de Windt, E.J.G. et al. Prevalence ofChlamydia trachomatis infection in a population of asymptomatic women in a screening program for cervical cancer. Eur. J. Clin. Microbiol. Infect. Dis. 8, 127–130 (1989). https://doi.org/10.1007/BF01963895

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