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Inactivity of terbinafine in a rat model of pulmonary aspergillosis

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Abstract

In a model of bronchopulmonary aspergillosis terbinafine did not improve survival of experimental animals in doses up to 80 mg/kg/day despite adequate lung concentrations. Pretreatment and aerosolization of the compound were also ineffective. Terbinafine was markedly less active in vitro when serum was used instead of Yeast-Nitrogen-Glucose-broth. It is concluded that a lack of bioavailability in the presence of serum may explain the lack of activity of terbinafine in experimental aspergillosis.

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Authors and Affiliations

  1. Infectious Diseases Service, Department of Medicine and Microbiology Laboratory, Memorial Sloan-Kettering Cancer Center, New York, New York, USA

    H. J. Schmitt, J. Andrade, F. Edwards, Y. Niki, E. Bernard & D. Armstrong

  2. Children's Hospital, Johannes Gutenberg University, Langenbeckstraße 1, 6500, Mainz, FRG

    H. J. Schmitt

Authors
  1. H. J. Schmitt
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  2. J. Andrade
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  3. F. Edwards
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  4. Y. Niki
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  5. E. Bernard
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  6. D. Armstrong
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Schmitt, H.J., Andrade, J., Edwards, F. et al. Inactivity of terbinafine in a rat model of pulmonary aspergillosis. Eur. J. Clin. Microbiol. Infect. Dis. 9, 832–835 (1990). https://doi.org/10.1007/BF01967386

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