Abstract
The validity of atraumatic measurements of regional cerebral blood flow (r.c.b.f) by intravenous injection of Xenon 133 has been studied in 17 patients with cerebrovascular diseases. The results were directly compared with those obtained in the same subjects using the intracarotid-injection method. Clearance curves obtained by the intravenous method were analysed by means of a bicompartmental model of blood circulation corrected for recirculation of the tracer. Use of different modes of intravenous injection and systematic analysis of the portion of the clearance curve usable for estimation of regional cerebral blood flow enabled the authors to define the optimal conditions for measurement of r.c.b.f. in subjects with cerebrovascular disorders. A predominant source of error was found to be the difficulty in defining the exact instant when clearance begins. As a result, the best conditions were as follows: slow injection (1 min) of tracer and analysis of the portion of clearance curve between 3 and 11 min after the beginning of the clearance. Under these conditions this atraumatic method is as precise in subjects with cerebrovascular disease as in those with normal cerebral circulation.
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Seylaz, J., Meric, P., Correze, J.L. et al. Analytical problems associated with the noninvasive measurements of cerebral blood flow in cerebrovascular diseases. Med. Biol. Eng. Comput. 18, 39–47 (1980). https://doi.org/10.1007/BF02442478
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DOI: https://doi.org/10.1007/BF02442478