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Cefotaxime and desacetyl cefotaxime in human bile

Cefotaxim und Desacetyl-Cefotaxim in der Galle des Menschen

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Summary

Ten patients were injected with 2 g cefotaxime i. v. The antibacterial activity in the bile was measured by the agar diffusion test and the concentrations of cefotaxime and desacetyl cefotaxime were determined by high performance liquid chromatography. The values found allow the use of cefotaxime in infectious biliary diseases.

Zusammenfassung

Zehn Patienten wurden je 2 g Cefotaxim i. v. injiziert. In der Galleflüssigkeit wurden die antibakterielle Aktivität mittels Agardiffusionstest und die Konzentrationen von Cefotaxim und Desacetyl-Cefotaxim mit Hochdruckflüssigkeitschromatographie bestimmt, Die gefundenen Werte erlauben den Einsatz von Cefotaxim bei infektiösen Gallenwegserkrankungen.

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Literature

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Authors and Affiliations

  1. Lehrstuhl für Pharmakologie der Universität Regensburg, Universitätsstraße 31, D-8400, Regensburg

    F. Kees,  E. Strehl,  P. Dominiak &  H. Grobecker

  2. Hoechst AG, D-6230, Frankfurt/M 80

    K. Seeger &  G. Seidel

  3. Reinhard-Nieter-Krankenhaus, Friedrich-Paffrath-Str. 100, D-2940, Wilhelmshaven

    B. Neuhaus &  L. Safrany

Authors
  1. F. Kees
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  2. E. Strehl
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  3. P. Dominiak
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  4. H. Grobecker
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  5. K. Seeger
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  6. G. Seidel
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  7. B. Neuhaus
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  8. L. Safrany
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Kees, F., Strehl, E., Dominiak, P. et al. Cefotaxime and desacetyl cefotaxime in human bile. Infection 11, 118–120 (1983). https://doi.org/10.1007/BF01641077

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  • DOI: https://doi.org/10.1007/BF01641077

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