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Herpes simplex virus type 2 infection of neonatal mice

Infizierung neugeborener Mäuse mit Herpes simplex-Virus Typ 2

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Summary

We have demonstrated that newborn mice can be infected orally with herpes simplex virus type 2. Transplacental and transvaginal transmission of herpes simplex virus type 2 did not occur in our mice. Failure to produce natural transvaginal infection in mice may be explained by the relatively short period of exposure to the virus during parturition. These experiments demonstrate that high oral doses of herpes simplex virus type 2 can produce disseminate herpes neonatal infection in mice and therefore may be useful in future investigations into the mechanism and the treatment of this disease.

Zusammensetzung

Wir haben nachgewiesen, daß neugeborene Mäuse oral mit Herpes simplex-Virus Typ 2 infiziert werden können. Bei unseren Mäusen trat keine transplazentäre oder transvaginale Übertragung des Herpes simplex-Virus Typ 2 auf. Das Ausbleiben einer natürlichen transvaginalen Infizierung bei Mäusen läßt sich durch die relativ kurze Expositionszeit gegenüber dem Virus während des Geburtsvorgangs erklären. Diese Versuche zeigen, daß hohe orale Dosen von Herpes simplex-Virus Typ 2 bei Mäusen eine disseminierte Neonatalinfektion bewirken können und diese Versuche daher bei künftigen Untersuchungen des Mechanismus und der Behandlung dieser Krankheit möglicherweise von Nutzen sind.

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Author notes

  1. D. A. Baker

    Present address: Department of Obstetrics and Gynecology, University of Vermont Medical Center, 05401, Burlington, Vermont, USA

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Hospital of the University of Pennsylvania, 19104, Philadelphia, Pennsylvania, USA

    D. A. Baker

  2. Professor Wistar Institute of Anatomy and Biology, University of Pennsylvania, 36th and Spruce Streets, 19104, Philadelphia, Pennsylvania, USA

    S. A. Plotkin

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  1. D. A. Baker
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  2. S. A. Plotkin
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Baker, D.A., Plotkin, S.A. Herpes simplex virus type 2 infection of neonatal mice. Infection 6, 158–161 (1978). https://doi.org/10.1007/BF01641904

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  • DOI: https://doi.org/10.1007/BF01641904

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