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Concentration and protein binding of cephalosporins in renal interstitial fluid, soft-tissue interstitial fluid, urine and serum

Konzentrationen und Eiweißbindung von Cephalosporinen in der interstitiellen Flüssigkeit von Subkutangewebe und Niere sowie im Urin und Serum

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Summary

Utilizing multiperforated capsules implanted in tissue, the concentrations of cephalothin, cefazolin and cefamandole in soft tissue interstitial fluid and renal interstitial fluid were measured simultaneously and compared with concentrations found in serum and urine in dogs. Antibiotic concentration in renal interstitial fluid was less than urinary levels but exceeded serum concentrations. A direct time-concentration relationship of these three structurally related antibiotics with different protein-binding in serum and renal interstitial fluid was found. This model helps illuminate the basic pharmacokinetics of antibiotic in the renal interstitium where pyelonephritis occurs.

Zusammenfassung

Mittels implantierter perforierter Kapseln wurde die Konzentration von Cephalotin, Cephazolin und Cefamandol in der interstitiellen Flüssigkeit des Subkutangewebes und der Niere gemessen und mit der Konzentration im Serum und Urin bei Hunden verglichen. Die Antibiotika-Konzentration in der renalen interstitiellen Flüssigkeit war niedriger als im Urin, überstieg aber die Serumkonzentration. Die drei strukturell ähnlichen Antibiotika mit unterschiedlicher Eiweißbindung im Serum und in der interstitiellen Flüssigkeit der Niere zeigten eine direkte Zeit-Konzentrationsabhängigkeit. Dieses Modell trägt zum grundsätzlichen Verständnis der Pharmakokinetik im Niereninterstitium bei, in dem sich die Pyelonephritis abspielt.

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  1. Urologische Universitätsklinik, Abteilung für Experimentelle Urologie der Gesamthochschule Essen, Hufelandstr. 55, D-4300, Essen 1

    H. -U. Eickenberg

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  1. H. -U. Eickenberg
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Eickenberg, H.U. Concentration and protein binding of cephalosporins in renal interstitial fluid, soft-tissue interstitial fluid, urine and serum. Infection 6 (Suppl 2), S233–S237 (1978). https://doi.org/10.1007/BF01638980

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  • DOI: https://doi.org/10.1007/BF01638980

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