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HLA and Behçet's disease in Northern Spain: Their lack of correlation with arthritis pattern

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Summary

We have studied the characteristics of arthritis present in 32 patients with Behçet's disease (BD), and how this arthritis is related to the HLA markers class I. 84% of the patients presented arthritis, the most common being monoarthritis as the initial presentation, and oligoarthritis in subsequent episodes. In 63% of the cases, the development was in episodes of acute/subacute arthritis. We found statistically significant association between antigens B-5 and B-51, and the group with BD, with a relative risk of 3.89 and 4.71 respectively. The attempt to relate markers B-5, B-51 and B-27 to the presence of arthritis as well as to its manifestation and further development was not conclusive.

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References

  1. O'Duffy, D., Behçet's disease. In: Textbook of Rheumatology. Eds: Kelly, W., Harris, E., Rudy, S., Sledge, C. Philadelphia, W.B. Saunders 1989, 1209–1214.

    Google Scholar 

  2. Shimizu, T., Ehrlich, G., Inaba, G., Hayashi, K. Behçet's Disease. Semin Arthritis Rheum 1979, 8, 223–260.

    Article  CAS  PubMed  Google Scholar 

  3. Calabro, J. Musculoskeletal Manifestations. Behçet's Disease: A Comtemporary Synopsis. Ed: Plotkin R., Calabro, J., O'Duffy D. New York, Futura Publishing, 1988, 10, 179–202.

    Google Scholar 

  4. Mason, M., Barnes, G. Behçet's syndrome with arthritis. Ann Rheum Dis 1969, 28, 95–103.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Barnes, G. Behçet's syndrome-Joint manifestations and synovial pathology. In: Behçet's Syndrome. Clinical and Immunologic Features. Proceedings of a conference sponsored by the Royal Society of Medicine. Eds: Lehner T., Barnes, G. London, Academic Press. 1979, 199–212.

    Google Scholar 

  6. Ohno, S., Aoki, K., Sugiura, S. et al. HLA B-5 and Behçet's disease. Lancet 1973, II 1383–1384.

    Article  Google Scholar 

  7. Yazici, H., Akokan, G., Yalcin, B. et al. The high prevalence of HLA B-5 in Behçet's disease. Clin Exp Immunol 1977, 30, 259–261.

    CAS  PubMed  PubMed Central  Google Scholar 

  8. O'Duffy, D., Taswell, H., Elverback, L. HLA antigens in Behçet's disease. J Rheumatol 1976, 3, 1–3.

    PubMed  Google Scholar 

  9. Chamberlain, M. Behçet's syndrome in 32 patients in Yorkshire. Ann Rheum Dis 1977, 36, 491–499.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Chajek-Shauk, T., Pisanty, S., Knobler, H. et al. HLA B-51 may serve as an immunogenetic marker for a subgroup of patients with Behçet's syndrome. Am J Med 1987, 83, 666–672.

    Article  Google Scholar 

  11. Lehner, T., Batchelor, J. Classification and immunogenetic basis of Behçet's syndrome. In: Behçet's syndrome. Clinical and immunological Features Proceeding of a conference sponsored by the Royal Society of Medicine. Eds: Lehner T., Barnes, G. London. Academic Press, 1979, 13–32.

    Google Scholar 

  12. Müftüoglu, A., Yazici, H., Yurdakul, S. et al. Lack of correlation of clinical manifestations with HLA antigens. Tissue Antigens 1981, 17, 226–230.

    Article  PubMed  Google Scholar 

  13. International Study Group for Behçet's Disease. Criteria for diagnosis of Behçet's disease. Lancet 1990, 335, 1078–1080.

    Google Scholar 

  14. Teresaky, P., McClelland, J. Mocrodoplet assay of human serum cytotoxins. Nature 1964, 204, 998.

    Article  Google Scholar 

  15. Yurdakul, S., Yazici, H., Tuzun, Y. et al. The arthritis of Behçet's disease: a prospective study. Ann Rheum Dis 1983, 42, 505–515.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Chajek, T., Fainaru, M. Behçet's disease. Report of 41 cases and a review of the literature. Medicine 1975, 54, 179–196.

    Article  CAS  PubMed  Google Scholar 

  17. Zizic, T., Stevens, M. The arthropaty of Behçet's disease. Johns Hopkins Med J 1975, 136, 243–250.

    CAS  PubMed  Google Scholar 

  18. Dilşen, N. Konice, M., Ovül, C. Arthritis patterns in Behçet's disease. In: Behçet's disease. Proceeding of an International Symposium of Behçet's Disease. Instanbul. Eds: Dilsen, N., Konice, M., Ovül, C. Amsterdam-Oxford, Excerpta Medica, 1979, 145–155.

    Google Scholar 

  19. Carporn, N., Higgs, E., Dieppe, P. et al. Arthritis in Behçet's syndrome. Br J Radiol 1983, 56, 87–91.

    Article  Google Scholar 

  20. Grana, J., Sanchez Burson, J., Atanes, A., Galdo, F. Estudio clinico de 15 pacientes con enfermedad de Behçet. Galicia Clin. 1987, 2, 39–43.

    Google Scholar 

  21. Chamberlain, M. Epidemiologic feature of Behçet's syndrome. In: Behçet's syndrome. Clinical and immunologic feature. Proceeding of a conference sponsored by the Royal Society of medicine. Eds: Lehner T., Barnes, G. London, Academic Press, 1979, 213–221.

    Google Scholar 

  22. Yazici, H., Tuzlaci, M., Yurdakul, S. A controlled survey of sacroiliitis in Behçet's disease. Ann Rheum Dis 1981, 40, 558–559.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Al-Rawi, Z., Sharquie, K., Khalifa, S. et al. Behçet's disease in Iraqui patients. Ann Rheum Dis 1986, 45, 987–990.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Kahan, A., Amor, B., Benhamou, C., Saporta, L. Association du syndrome de Behçet et de la spondylarthrite ankylosante. Ann Med Intern 1982, 133, 573–575.

    CAS  Google Scholar 

  25. Strachan, K., Wigzell, F. Polyarthritis in Behçet's multiple symptom complex. Ann Rheum Dis 1963, 22, 26–35.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Ryder, L. An HLA map of Europe. Hum Hered 1978, 28, 171–200.

    Article  CAS  PubMed  Google Scholar 

  27. Tiwari, J., Teresaky, P. HLA and Disease Associations New York, Springer Verlag. 1986, 4–14.

    Google Scholar 

  28. Llorente, L., Campillo, F., Estudio del sistema HLA en la poblacion espanola. Sangre 1976, 24, 271–276.

    Google Scholar 

  29. Graña, J., Sanchez-Burson, J., Atanes, A. et al. Enfermedad de Behçet y HLA en Galicia. Rev Esp Reumatol 1987, 14A, 214–217.

    Google Scholar 

  30. Hamza, H., Ben Hayed, H., Sohier, R., Betuel, H. Frequence de l'antigene HLA B-5 au course de la maladie de Behçet. Nouv Presse Med 1978, 7, 3263.

    CAS  PubMed  Google Scholar 

  31. Brautbar, C., Chajek, T., Ben-Tuvia, S. et al. A genetic study of Behçet's disease in Israel. Tissue Antigens 1978, 11, 113–120.

    Article  CAS  PubMed  Google Scholar 

  32. Roux, H., Richard, P., Arrighi, A. et al. Autochtonous Behçet's disease. A propos of 73 cases. Rev Rhum Mal Osteoartic. 1989, 56, 383–388.

    CAS  PubMed  Google Scholar 

  33. Zervas, J., Vayapoulos, G., Sakellaropoulos, P. et al. HLA antigens and Adamantiades-Behçet's disease in Greeks. Clin Exp Rheumatol 1988 6, 277–280.

    CAS  PubMed  Google Scholar 

  34. Takano, M., Miyajima, T., Kiuchi, M. Behçet's disease and the HLA system. Tissue Antigens 1976, 8, 95–99.

    Article  CAS  PubMed  Google Scholar 

  35. Ersoy, F., Berkel, I., Firat, T. et al. HLA antigens associated with Behçet's disease. Arch Dermatol 1977, 113, 1720–1721.

    Article  CAS  PubMed  Google Scholar 

  36. Lehner, T., Wesh, K., Batchelor, J. The relationship of HLA B and DR phenotypes to Behçet's syndrome, recurrent oral ulceration and the class of immune complexes. Immunology 1982, 47, 581–587.

    CAS  PubMed  PubMed Central  Google Scholar 

  37. Yazici, H., Chamberlain, A., Schreuder, I. et al. HLA antigens in Behçet's disease: a reappraisal by comparative study of Turkish and British patients. Ann Rheum Dis 1980, 39, 344–348.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Ohno, S., Matchuda, H. Studies of HLA antigens in Behçet's disease in Japan, In: Recent advances in Behçet's disease. Eds.: Lehner T., Barnes, G. London, Royal Society of Medicine Services. 1986, 11–16.

    Google Scholar 

  39. Chamberlain, A. A family study of Behçet's syndrome. Ann Rheum Dis 1978, 37, 459–465.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Haim, S., Gideoni, O., Barzilay, A. The histocompatibility antigens in patients with Behçet's disease. Acta Dermatol Venereol 1977, 57, 243–245.

    CAS  Google Scholar 

  41. Imbert, I., Legros, P., Prigent, D. et al. Articular manifestations of Behçet's disease. A propos of 65 cases. Rev Rhum Mal Osteoartic. 1987, 54, 93–96.

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Rheumatology Unit., Hospital Juan Canalejo, La Coruña, Spain

    J. Graña Gil, A. Atanes Sandoval & F. Galdo Fernandez

  2. Preventive Medicine Unit, Hospital Juan Canalejo, La Coruña, Spain

    J. Sanchez Burson & M. Rosales Rodriguez

  3. Immunology Unit., Hospital Juan Canalejo, La Coruña, Spain

    J. Sanchez Burson & C. Alonso Blanco

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  1. J. Sanchez Burson
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  2. J. Graña Gil
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  4. A. Atanes Sandoval
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  5. C. Alonso Blanco
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  6. F. Galdo Fernandez
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Burson, J.S., Gil, J.G., Rodriguez, M.R. et al. HLA and Behçet's disease in Northern Spain: Their lack of correlation with arthritis pattern. Clin Rheumatol 11, 261–264 (1992). https://doi.org/10.1007/BF02207969

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