Summary
We describe the long term results of treatment with interferon (IFN) in two patients with cryoglobulinemia and chronic hepatitis related to Hepatitis C virus (HCV). Our results suggest that interferon may induce long remission in cryoglobulinemia associated with HCV infection and that the effect of IFN is not dependant on the effect on liver function, but results of its antiviral activity.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Pascual, M., Perrin, L., Giostra, E., Schifferli, J.A. Hepatitis C virus in patients with cryoglobulinemia type II. J Infect Dis 1990, 162, 569–570.
Knox, T.A., Hillyer, C.D., Kaplan, M.M., Berkman, E.M. Mixed cryoglobulinaemia responsive to interferon alpha. Am J Med 1991, 91, 554–555.
Durand, J.M., Kaplanski, G., Lefevre, P., Richard, M.A., Andrac L, Trepo C, Soubeyrand, J. Effect of Interferon alpha 2b on cryoglobulinemia related to hepatitis C virus infection. J Infect Dis 1992, 165, 778–779.
Taillan, B., Ferrari, E., Garnier, G., Pesce, A., Fuzibet, J.G., Dujardin, P. Low-dose interferon alpha for mixed cryoglobulinemia associated with hepatitis C virus. Am J Med 1992, 93, 476.
Agnello, V., Chung, R.T., Kaplan, L.M. The role for hepatitis C virus infection in type II cryoglobulinemia. N Engl J Med 1992, 327, 1490–1495.
Marcellin, P., Descamps, V., Martinot-Peignoux, M., Larzul, D., Xu, L., Boyer, N., Pham, B.N., Crickx, B., Guillevin, L., Belaich, S., Erlinger, S., Benhamou, S. Cryoglobulinemia with vasculitis associated with hepatitis C virus infection. Gastroenterology 1993, 104, 272–277.
Garson, J.A., Tedder, R.S., Briggs, M., Tuke, P., Glazebrook, J.A., Trute, A., Parker, D., Barbara, J.A.J., Contreras, M., Aloysius, S. Detection of hepatitis C viral sequences in blood donations by “nested” polymerase chain reaction and prediction of infectivity. Lancet 1990, 335, 1419–1422.
Casato, M., Lagana, B., Antonelli, G., Dianzani, F., Bonomo, L. Long-term results of therapy with interferon alpha for type II essential mixed cryoglubulinemia. Blood 1991, 78, 3142–3147.
Peters, M., Ambrus, J.L., Zheleznyak, A., Walling, D., Hoofnagle, J.H. Effect of interferon-alpha on immunoglobulins synthesis by human B cells. J Immunolol 1986, 137, 3153–3157.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Durand, J.M., Cretel, E., Kaplanski, G. et al. Long-term results of therapy with interferon alpha for cryoglobulinemia associated with hepatitis C virus infection. Clin Rheumatol 13, 123–125 (1994). https://doi.org/10.1007/BF02229881
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02229881