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1,25-Dihydroxyvitamin D-related hypercalcemia in lymphoma: Two case reports

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Summary

We report two patients with non-Hodgkin's lymphoma in whom hypercalcemia and elevated 1,25 dihydroxyvitamin D (1,25-(OH)2D3) levels developed in the absence of any lytic bone lesions. Hypercalcemia responded only transiently to glucocorticoids which were ill tolerated. Intravenous APD administration was needed to circumvene hypercalcemia. Humoral hypercalcemia of malignancy is discussed. Our cases confirm that hypercalcemia associated with elevated 1,25-(OH)2D3 may occur in malignant lymphoma.

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Authors and Affiliations

  1. Department of Rheumatology, St-Luc University Hospital, Louvain University in Brussels, avenue Hippocrate 10, B-1200, Brussels, Belgium

    J. P. Devogelaer, M. Lambert, B. Boland, C. Godfraind, H. Noel & C. Nagant De Deuxchaisnes

  2. Department of Internal Medicine, Louvain University in Brussels, avenue Hippocrate 10, B-1200, Brussels, Belgium

    M. Lambert & B. Boland

  3. Department of Pathology, St-Luc University Hospital, Louvain University in Brussels, avenue Hippocrate 10, B-1200, Brussels, Belgium

    C. Godfraind & H. Noel

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  1. J. P. Devogelaer
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  6. C. Nagant De Deuxchaisnes
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Devogelaer, J.P., Lambert, M., Boland, B. et al. 1,25-Dihydroxyvitamin D-related hypercalcemia in lymphoma: Two case reports. Clin Rheumatol 9, 404–410 (1990). https://doi.org/10.1007/BF02114405

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