Abstract
Cerebrospinal fluid (CSF) samples from patients undergoing lumbar puncture for suspected neurological diseases were fractioned into macromolecular (MW>3000 Daltons) and small molecule components (MW<3000 Daltons). The macromolecular component was tested for its interference with GABA stimulation of36Cl− accumulation in rat cerebral cortex microsacs.
For many pathologies, no interference was apparent; an exception was two patients with Parkinson's disease in whom there were clear signs of stimulated GABA activity. This last result seems worthy of further investigation.
Sommario
Campioni di liquido cefalo-rachidiano di pazienti analizzati per casi di sospette malattie neurologiche sono stati separati nella componente macromolecolare (Peso Molecolare >3000 Daltons) ed in quella delle piccole molecole (PM<3000 Daltons). La c omponente macromolecolare è stata testata per la sua possibile interferenza con l'accumulo di36Cl−, stimolato dal GABA, in “microsacs” della corteccia cerebrale di ratto.
Per molte patologie non è stata rilevata alcuna interferenza. Fanno eccezione i pochi (2) casi di morbo di Parkinson; in entrambi i casi vi è una chiara stimolazione dell'attività GABAergica. Quest' ultima indicazione sembra degna di ulteriori indagini.
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Rapallino, M.V., Cupello, A. & Leonardi, A. Screening of the macromolecular component of CSF from various pathologies for its interference with GABAA receptor function. Ital J Neuro Sci 16, 643–646 (1995). https://doi.org/10.1007/BF02230915
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DOI: https://doi.org/10.1007/BF02230915