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Long-term treatment with idebenone and riboflavin in a patient with MELAS

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Abstract

We report a patient with MELAS treated for 24 months with idebenone and riboflavin, during which no stroke-like episodes occured. Moreover neurological symptoms clearly improved, and a recovery of brain MRI and EEG abnormalities was observed. We conclude that the combined treatment with idebenone and riboflavin may restore the metabolic impairment in MELAS, possibly improving the long-term prognosis in these patients.

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Authors and Affiliations

  1. Division of Neurology, Campo di Marte Hospital, I-55100 Lucca, Italy, , , , , , IT

    A. Napolitano, S. Salvetti, M. Vista & C. Giraldi

  2. Department of Neuroscience, University of Pisa, Pisa, Italy, , , , , , IT

    V. Lombardi & G. Siciliano

Authors
  1. A. Napolitano
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  2. S. Salvetti
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  3. M. Vista
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  4. V. Lombardi
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  5. G. Siciliano
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  6. C. Giraldi
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Napolitano, A., Salvetti, S., Vista, M. et al. Long-term treatment with idebenone and riboflavin in a patient with MELAS. Neurol Sci 21 (Suppl 3), S981 (2000). https://doi.org/10.1007/s100720070015

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  • DOI: https://doi.org/10.1007/s100720070015

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