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Evidence of excretion of chlorinated hydrocarbon pesticides by the human liver

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Conclusions

  1. 1.

    The liver excretes DDT and dieldrin into the bile.

  2. 2.

    The dieldrin content of bile from a worker having very high tissue stores is much greater than it is in persons with no occupational exposure. This suggests the existence of substrate-responsive excretory mechanisms.

  3. 3.

    We have tentatively identified the aldehyde degradation product of dieldrin in adipose fat, bile,and gall stone. The ketone product has not been found in fat, bile, or gall stone.

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References

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Author information

Authors and Affiliations

  1. The Arizona Community Studies Pesticide Project, Department of Entomology, University of Arizona, 85721, Tucson, Ariz.

    E. H. Paschal (Chemist), C. C. Roan (Project Director) & D. P. Morgan (Epidemiologist)

Authors
  1. E. H. Paschal
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  2. C. C. Roan
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  3. D. P. Morgan
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Additional information

Supported by Contract 68-02-0718 between the University of Arizona and the Environmental Protection Agency. Reprint requests should be addressed to Department of Entomology, University of Arizona, Tucson, Arizona 85721.

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Paschal, E.H., Roan, C.C. & Morgan, D.P. Evidence of excretion of chlorinated hydrocarbon pesticides by the human liver. Bull. Environ. Contam. Toxicol. 12, 547–554 (1974). https://doi.org/10.1007/BF01684917

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  • DOI: https://doi.org/10.1007/BF01684917

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