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Further data on the effect of galactose on bone tissue

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Abstract

The bone tissue levels of galactose-1-P have been found to be a function of the concentration of galactose in blood.In vitro, the glucose-6-phosphate dehydrogenase (bone isoenzyme) was competitively inhibited by galactose-1-P. Galactose or galactitol were found ineffective. Therefore, the previously reported depressed activity of bone glucose-6-phosphate dehydrogenase in galactose-fed rats should be interpreted as mediated by galactose-1-P. When compared with their controls, galactose-fed rats showed a significantly lower growth rate which was reflected in a lower bone collagen content and in a lower percentage of salt soluble collagen.

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Authors and Affiliations

  1. Departamento de Ciencias Fisiológicas, Facultad de Medicina, Universidad Nacional de Rosario, Santa Fe 3100, Rosario, Argentina

    Martha E. Locatto, María C. Fernandez &  R. C. Puche

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  1. Martha E. Locatto
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  2. María C. Fernandez
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  3. R. C. Puche
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Locatto, M.E., Fernandez, M.C. & Puche, R.C. Further data on the effect of galactose on bone tissue. Calc. Tis Res. 16, 153–155 (1974). https://doi.org/10.1007/BF02008221

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  • DOI: https://doi.org/10.1007/BF02008221

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