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Effects ofSolanum malacoxylon on embryonic bonein vitro and on isolated mitochondria

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Abstract

An active constituent of the leaves ofSolanum malacoxylon (SM) is shown to promote calcium resorption and citrate production in embryonic chick frontal bone culturedin vitro. When injected into rats, SM reduces the ATP content of liver and kidneys. This phenomenon may be related to the ability of SM to stimulate mitochondrial ATPase activity at pH 9.4. SM significantly reduces the concentration of phosphate necessary to alter the uptake of calcium and respiration of siolated mitochondria. The data suggest that SM influences calcium and phosphate metabolism by affecting ion movements into and out of mitochondria.

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Authors and Affiliations

  1. Departamento de Ciencias Fisiológicas, Facultad de Medicina, Universidad Nacional de Rossario, Santa Fe 3100, Rosario, Argentina

    R. C. Puche & M. E. Locatto

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  1. R. C. Puche
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  2. M. E. Locatto
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Puche, R.C., Locatto, M.E. Effects ofSolanum malacoxylon on embryonic bonein vitro and on isolated mitochondria. Calc. Tis Res. 16, 219–226 (1974). https://doi.org/10.1007/BF02008229

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  • DOI: https://doi.org/10.1007/BF02008229

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