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The reversibility of disuse osteoporosis

Studies of bone density, bone formation, and cell proliferation in bone tissue

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Summary

One hind leg of 80 adult rats of the Sprague-Dawley strain was made osteoporotic by immobilization for 9 weeks. Osteoporosis was noted in both the femur and the tibia when the hydrated gross bone density and the bone surface areas were measured. No signs of reversibility were observed during 10 weeks after the period of immobilization. Tetracycline and DCAF labelling failed to show significant signs of increased bone formation during the 10 weeks after remobilization. At the moment of remobilization and for some weeks thereafter, there were signs of depressed mitotic activity in the bone cells when expressed as the3H-thymidine/DNA ratio. The conclusion was that neither the cell-proliferation rate nor the cellular activity increases sufficiently for restitution of the disuse osteoporosis.

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References

  • Hinegardner, R.I.: An improved fluorometric assay for DNA. Anal. Biochem.39, 197–201 (1971)

    Article  PubMed  Google Scholar 

  • Hughes, W.L.: The metabolic stability and deoxyribonucleic acid. In: Kinetics of cellular proliferation (F. Stohlman, jr., ed.), p. 83. New York and London: Grune and Stratton 1959

    Google Scholar 

  • Hughes, W.L.: Cellular proliferation in the mouse as revealed by autoradiography with tritiated thymidine. Proc. Nat. Academ. Sci.44, 476 (1958)

    Google Scholar 

  • Jones, I., Lemperg, R.: Determination of DNA in bone tissue. In preparation (1976)

  • Kember, N.F.: Cell division in enchondral ossification. J. Bone Jt Surg.B-42, 824–839 (1960)

    Google Scholar 

  • Kissane, J.M., Robins, E.: The fluorometric measurement of deoxyribonucleic acid in animal tissues with special reference to the central nervous system. J. Biol. Chem.233, 184–188 (1958)

    PubMed  Google Scholar 

  • Lindgren, J.U.: The effect of thyroparathyroidectomy on the development of disuse osteoporosis in adult rats. Clin. Orthop. Rel. Res.118, 251–256 (1976)

    Google Scholar 

  • Mattson, S.: The reversibility of disuse osteoporosis. Experimental studies in the adult rat. Acta orthop. scand. suppl. No.144 (1972)

  • Mueller, K., Trias, A., Ray, R.D.: Bone density and composition. J. Bone Jt Surg.48-A, 138–148 (1966)

    Google Scholar 

  • Nilsson, B.E.: Post-traumatic osteopenia. Acta orthop. scand. suppl. No.91 (1966)

  • Snedecor, G.W., Cochran, W.C.: Statistical methods. Ames: Iowa State University Press 1967

    Google Scholar 

  • Telhag, H., Gudmundson, C.: Nucleic acids in degenerative joint disease. Clin. Orthop.88, 247–251 (1972)

    PubMed  Google Scholar 

  • Wagner, H.: Präsenile Osteoporose. Physiologie des Knochenumbaus und Messung der Spongiosadichte. Stuttgart: Georg Thieme 1965

    Google Scholar 

  • Westlin, N.E.: Loss of bone mineral after Colles' fracture. Clin. Orthop. Rel. Res.102, 194–199 (1974)

    Google Scholar 

Download references

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Lindgren, U., Mattsson, S. The reversibility of disuse osteoporosis. Calc. Tis Res. 23, 179–184 (1977). https://doi.org/10.1007/BF02012784

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  • DOI: https://doi.org/10.1007/BF02012784

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