Abstract
The metacarpal bone mineral density (BMD) and metacarpal index (MCI) of the second metacarpal bone were measured by computed X-ray densitometry (CXD) (Teijin Ltd., Tokyo), which we have established with the development of microdensitometry of radiographs. In this study, we evaluated the basic attributes of this CXD method and determined the age-related changes in both metacarpal measurements in normal Japanese women. The precision in vivo was measured in eight subjects. The precision errors [coefficient of variation (CV)] were 0.2–1.2% CV for metacarpal BMD and 0.4–2.0% CV for MCI, respectively. We have obtained low precision error and more rapid analysis, within 3 minutes respectively, compared with the previous methods. Age-related changes in the metacarpal measurements were evaluated in 1438 normal women. Both measurements showed the most significant decrease in the sixth decade of life. The rate of decrease in the sixth decade was 1.6%/year for metacarpal BMD and 1.5%/year for MCI. On comparison between metacarpal BMD by CXD and spine BMD using dual energy X-ray absorptiometry (DXA) in 248 normal women with and without menstruation, the two measurements were found to be similarly decreased in the subjects within 5 years after menopause. There was also no significant difference in the Z-score between metacarpal BMD and spine BMD within 5 years after menopause. These results indicate that early postmenopausal bone loss occurs not only in the spine but also in the metacarpal bone. The metacarpal BMD for patients with osteoporosis was significantly lower than that for age-matched normal controls, although the Z-score for spine BMD (-1.46) was significantly better than that for metacarpal BMD (-0.82). In conclusion, because CXD has excellent low precision error and is widely available at relatively low cost, it appears potentially to be applicable to problems in the diagnosis and management of osteoporosis, when used in association with DXA.
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References
Barnett E, Nordin BEC (1960) The radiological diagnosis of osteoporosis: a new approach. Clin Radiol 11:166–174
Dequeker J (1976) Quantitative radiology: radiogrammetry of cortical bone. Br J Radiol 49:912–920
Evans RA, McDonnell GD, Schieb M (1978) Metacarpal cortical area as an index of bone mass. Br J Radiol 51:428–431
Garn SM, Rohmann CG, Wagner B, Davila GH, Ascoli W (1969) Population similarities in the onset and rate of adult endosteal bone loss. Clin Orthop 65:51–60
Morgan DB, Spiers FW, Pulvertraft CN, Fourman P (1967) The amount of bone in the metacarpal and the phalanx according to age and sex. Clin Radiol 18:101–108
Trouerbach WT, Hoornstra K, Birkenhager JC, Zwamborn AW (1985) Roentgendensitometric study of the phalanx. Diagn Imag Clin Med 54:64–77
Trouerbach WT, Birkenhaeger JC, Schmitz PIM, van Hemert AM, van Saase JLCM, Collette HJA, Zwamborn AW (1988) A cross-sectional study of age-related loss of mineral content of phalangeal bone in men and women. Skeletal Radiol 17:338–343
Oguti S (1987) X-ray photodensitometric study of the second metacarpal. J Jpn Orthop Assoc 61:1389–1404
Cosman F, Herrington B, Himmelstein S, Lindsay R (1991) Radiographic absorptiometry: a simple method for determination of bone mass. Osteoporosis Int 2:34–38
Colbert C, Garrett C (1969) Photodensitometry of bone roentgenograms with an on-line computer. Clin Orthop 65:39–45
Strid KG, Kalebo P (1988) Bone mass determination from microradiographs by computer-assisted videodensitometry. Acta Radiologica 4:465–472
Kalebo P, Strid KG (1988) Bone mass determination from microradiographs by computer-assisted videodensitometry. Acta Radiologica 5:611–617
Inoue T, Kushida K, Yamashita G (1980) Radiological assessment of bone density using microdensitometer. Kotsutaisha Gakkai Zasshi 13:187–195 (in Japanese)
Inoue T, Kushida K, Miyamoto T, Sumi Y, Orimo H, Yamashita G (1983) Quantitative assessment of bone density. J Jpn Orthop Assoc 57:1923–1936
Taniguchi M, Kushida K, Denda M, Fujiwara T, Inoue T (1989) A study of 2nd metacarpal bone mineral density by dual energy X-ray absorptiometry. Cent Jpn J Orthop Trauma 33:970–971 (in Japanese)
Orimo H, Shiraki M (1993) Clinical evaluation of menatetrenone (vitamin K2) in the treatment of involutional osteoporosis. Proc 4th Intl Symp on Osteoporosis, pp 148–149
Matsumoto C, Kushida K, Orimo H, Koshikawa S, Shiraki M, Akimoto T, Inoue T, Togawa H (1991) A new computed x-ray densitometer and its performance. J Clin Exp Med (Igaku no Ayumi) 156:741–742
Kalla AA, Meyers OL, Parkyn ND, Kotze TJvW (1989) Osteoporosis screening—radiogrammetry revisited. Br J Rheumatol 28:511–517
Rico H, Hernandez ER (1989) Bone radiogrametry: caliper versus magnifying glass. Calcif Tissue Int 45:285–287
Matsumoto C, Kushida K, Sumi Y, Yamazaki K, Taniguti M, Inoue T (1990) Development of computed x-ray densitometry and its application. Proc 3rd Intl Symp on Osteoporosis, pp 772–775
Pouilles JM, Tremollieres F, Todorovsky N, Ribot C (1991) Precision and sensitivity of dual-energy x-ray absorptiometry in spinal osteoporosis. J Bone Miner Res 6:997–1002
Larcos G, Wahner HW (1991) An evaluation of forearm bone mineral measurement with dual-energy x-ray absorptiometry. J Nucl Med 32:2101–2106
Mazess RB (1981) On aging bone loss. Clin Orthop 165:239–252
Kin K, Kushida K, Yamazaki K, Okamoto S, Inoue T (1988) Bone mineral density of the spine in normal Japanese subjects. J Bone Miner Metab 8:53–56
Mazess RB, Barden HS, Ettinger M, Johnston C, Dawson-Hughes B, Baran D, Powell M, Notelovitz M (1987) Spine and femur density using dual-photon absorptiometry in US white women. Bone Miner 2:211–219
Geusens P, Dequeker J, Verstraeten A, Nijs J (1986) Age-, sex-, and menopause-related changes of vertebral and peripheral bone: population study using dual and single photon absorptiometry and radiogrammetry. J Nucl Med 27:1540–1549
Kin K, Kushida K, Yamazaki K, Okamoto S, Inoue T (1991) Bone mineral density of the spine in normal Japanese subjects using dual-energy x-ray absorptiometry: effect of obesity and menopausal status. Calcif Tissue Int 49:101–106
Alhava EM (1991) Bone density measurements. Calcif Tissue Int 49:s21-s23
Wishart JM, Horowitz M, Bochner M, Need AG, Nordin BEC (1993) Relationships between metacarpal morphometry, forearm and vertebral bone density and fractures in postmenopausal women. Br J Radiol 66:435–440
Meena HE (1991) Improved vertebral fracture threshold in postmenopausal osteoporosis by radiogrammetric measurements: its usefulness in selection for preventive therapy. J Bone Miner Res 6:9–14
Cooper C, Wickham C, Walsh K (1991) Appendicular skeletal status and hip fracture in the elderly: 14-year prospective data. Bone 12:361–364
Riis BJ, Christiansen C (1988) Measurement of spinal or peripheral bone mass to estimate early postmenopausal bone loss? Am J Med 84:646–653
Black DM, Cummings SR, Genant HK, Nevitt MC, Palermo L, Browner W (1992) Axial and appendicular bone density predict fractures in older women. J Bone Miner Res 7:633–638
Eastell R, Wahner HW, O'Fallon WM, Amadio PC, Melton LJ III, Riggs BL (1989) Unequal decrease in bone density of lumbar spine and ultradistal radius in Colles' and vertebral fracture syndromes. J Clin Invest 83:168–174
The present state of national nutrition (1991) Japanese Ministry of Health and Welfare, Tokyo
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Matsumoto, C., Kushida, K., Yamazaki, K. et al. Metacarpal bone mass in normal and osteoporotic Japanese women using computed X-ray densitometry. Calcif Tissue Int 55, 324–329 (1994). https://doi.org/10.1007/BF00299308
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DOI: https://doi.org/10.1007/BF00299308