Skip to main content
SpringerLink
Log in

Vitamin D analogs: From renal bone disease to osteoporosis

  • Satellite Symposium on New Aspects in Therapy With Active Vitamin D Derivatives May 19, 1996 Amsterdam, The Netherlands
  • Published:
Calcified Tissue International Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Kanis JA (1985) Pathogenesis of renal bone disease. MD Thesis, University of Sheffield, UK

    Google Scholar 

  2. Kanis JA, Earnshaw M, Henderson RG, Heynen G, Ledingham J (1977) Correlation of clinical, biochemical and skeletal responses to la-hydroxy vitamin D3 in renal bone disease. Clin Endocrinol 7s:45–50

    Article  Google Scholar 

  3. Malluche HH, Ritz E, Lange HP, Kutshera J, Hodgson M, Seiffert U (1976) Bone histology in incipient and advanced renal failure. Kidney Int 9:355–362

    Article  CAS  PubMed  Google Scholar 

  4. Cundy T, Hand DJ, Oliver DO, Woods CG, Wright FW, Kanis JA (1985) Who gets renal bone disease before beginning dialysis? Br Med J 290:271–275

    Article  CAS  Google Scholar 

  5. Ellis HA, Peart KM (1973) Azotaemic renal osteodystrophy-a quantitative study on iliac bone. J Clin Pathol 26:83–101

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  6. Kanis JA, Cundy T, Hamdy NAT (1988) Renal osteodystrophy. Baillieres Clin Endocrinol Metab 2:193–241

    Article  CAS  PubMed  Google Scholar 

  7. Malluche HH, Faugere M-C (1990) Renal bone disease 1990: an unmet challenge for the nephrologist. Kidney Int 38:193–211

    Article  CAS  PubMed  Google Scholar 

  8. Massry SG, Ritz E (1978) The pathogenesis of secondary hyperparathyroidism of renal failure—Is there a controversy? Arch Intern Med 138:853–856

    PubMed  Google Scholar 

  9. Slatopolsky E, Calgar S, Pennell JP, Taggart DB, Canterbury JM, Reiss E, Bricker NS (1971) On the pathogenesis of hyperparathyroidism in chronic experimental renal insufficiency in the dog. J Clin Invest 50:492–499

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  10. Bricker NS (1972) On the pathogenesis of the uremic state. An exposition of the “trade-off hypothesis.” N Engl J Med 286: 1093–1099

    Article  CAS  PubMed  Google Scholar 

  11. Llach F, Massry SG, Singer FR, Kurokawa K, Kaye JH, Coburn JW (1975) Skeletal resistance to endogenous parathyroid hormone in patients with early renal failure. A possible cause for secondary hyperparathyroidism. J Clin Endocrinol Metab 41:339–345

    Article  CAS  PubMed  Google Scholar 

  12. Llach F, Massry SG (1985) On the mechanism of secondary hyperparathyroidism in moderate renal insufficiency. J Clin Endocrinol Metab 61:601–606

    Article  CAS  PubMed  Google Scholar 

  13. Portale AA, Booth BE, Halloran BP, Morris RC (1984) Effect of dietary phosphorus on circulating concentrations of 1,25-dihydroxyvitamin D and immunoreactive parathyroid hormone in children with moderate renal insufficiency. J Clin Invest 73:1580–1589

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  14. Lopez-Hilker S, Galceran T, Chan YL, Rapp N, Martin KJ, Slatopolsky E (1986) Hypocalcemia may not be essential for the development of secondary hyperparathyroidism in chronic renal failure. J Clin Invest 78:1097–1102

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  15. Cundy T, Hamdy NAT, Kanis JA (1988) Factors modifying the secretion and action of parathyroid hormone in renal failure. Contrib Nephrol 64:5–15

    CAS  PubMed  Google Scholar 

  16. Massry SG, Stein R, Garty J, Areff AI, Coburn JW, Norman AW (1975) Skeletal resistance to the calcemic action of parathyroid hormone in uremia: role of 1,25(OH)2D3. Kidney Int 9:467–474

    Article  Google Scholar 

  17. Somerville PJ, Kaye M (1978) Resistance to hyperparathyroid hormone in renal failure: role of vitamin D metabolites. Kidney Int 14:245–254

    Article  CAS  PubMed  Google Scholar 

  18. Szabo A, Merke J, Beier E, Mall G, Ritz E (1989) 1,25(OH)2 vitamin D inhibits parathyroid cell proliferation in experimental uraemia. Kidney Int 35:1049–1056

    Article  CAS  PubMed  Google Scholar 

  19. Cantley LK, Russell J, Lettieri D, Sherwood LM (1985) 1,25-dihydroxyvitamin D3 suppresses parathyroid hormone secretion from parathyroid cells in tissue culture. Endocrinology 117:2114–2119

    Article  CAS  PubMed  Google Scholar 

  20. Silver J, Russell J, Sherwood LM (1985) Regulation by vitamin D metabolites of messenger ribonucleic acid for pre-proparathyroid hormone in isolated bovine parathyroid cells. Proc Natl Acad Sci 82:4270–4273

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  21. Silver J, Naveh-Many T, Mayer H, Schmelzer HJ, Popovtzer MM (1986) Regulation of vitamin D metabolites of parathyroid hormone gene transcription in vivo by the rat. J Clin Invest 78:1296–1301

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  22. Slatopolsky E, Weerts C, Thielan J, Horst R, Harter H, Martin KJ (1984) Marked suppression of secondary hyperparathyroidism by intravenous administration of 1,25-dihydroxy-cholecalciferol in uremic patients. J Clin Invest 74:2136–2143

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  23. Brickman AJ, Coburn JW, Massry SG, Norman AW (1974) 1,25-dihydroxyvitamin D3 in normal man and in patients with renal failure. Ann Int Med 80:161–168

    Article  CAS  PubMed  Google Scholar 

  24. Kanis JA, Cundy T, Earnshaw M, Henderson RG, Heynen G, Naik R, Russell RGG, Smith R, Woods CG (1979) Treatment of renal bone disease with 1-hydroxylated derivatives of vitamin D. Quart J Med 48:289–322

    CAS  PubMed  Google Scholar 

  25. Coburn JW, Brickman AS, Sherrard DJ, Singer FR, Baylink DJ, Wong ECG, (1977) Clinical efficacy of 1,25(OH)2D3 in renal osteodystrophy. In: Norman AW, Schaefer K, Coburn JW, DeLuca HF, Fraser D, Grigoleit H, von Herrath D (eds) Vitamin D: biochemical, chemical and clinical aspects relating to calcium metabolism. Walter deGruyter, Berlin, pp 657–666

    Google Scholar 

  26. Sharman VL, Brownjohn AM, Goodwin FJ, Heately W, Manning RM, O’Riordan JLH, Papapoulos SE, Marsh FP (1982) Long-term experience of alfacalcidol in renal osteodystrophy. Quart J Med 51:271–278

    CAS  PubMed  Google Scholar 

  27. Kanis JA, Earnshaw M, Heynen G, Ledingham JGG, Russell RGG, Smith R, Walton RJ (1977) Renal osteodystrophy in nondialysed adolescents: long-term treatment with 1-hydroxycholecalciferol. Archs Dis Child 52:473–481

    Article  CAS  Google Scholar 

  28. Kanis JA, Russell RGG (1977) Rate of reversal of hypercalcaemia induced by vitamin D3 and its 1α-hydroxylated derivatives. Br Med J 1:78–81

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  29. Goodman WG, Coburn JW (1992) The use of 1,25-dihydroxy-vitamin D3 in early renal failure. Ann Rev Med 43:227–237

    Article  CAS  PubMed  Google Scholar 

  30. Naik RB, Cundy T, Robison BHB, Russell RGG, Kanis JA (1981) Effects of vitamin D metabolites and analogues on renal function. Nephron 28:17–25

    Article  CAS  PubMed  Google Scholar 

  31. Hamdy NAT, Kanis JA, Beneton MNC, Brown CB, Juttman JR, Jordans JGM (1995) Effect of alfacalcidol on the natural history of renal bone disease in mild to moderate renal failure. Br Med J 310:358–363

    Article  CAS  Google Scholar 

  32. Gallagher JC, Riggs BL, Eisman J, Hamstra A, Arnaud SB, DeLuca HF (1979) Intestinal absorption and serum vitamin D metabolites in normal subjects and osteoporosis patients: effect of age and dietary calcium. J Clin Invest 64:729–736

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  33. Kanis JA (1994) Osteoporosis: Blackwell Scientific Publishers, Oxford

    Google Scholar 

  34. Lips P, Netelenbos JC, Jongen MJM, (1982) Histomorphometric profile and vitamin D status in patients with femoral neck fractures. Met Bone Dis Rel Res 4:89–93

    Google Scholar 

  35. Hordon LD, Peacock M (1990) Osteomalacia and osteoporosis in femoral head fracture. Bone Miner 11:147–159

    Google Scholar 

  36. Lips P, van Ginkel FC, Netelenbos JC, Wiersinga A, van der Wijgh W (1990) Lower mobility and markers of bone resorption in the elderly. Bone Miner 9:45–57

    Article  Google Scholar 

  37. Ranstam J, Kanis JA (1995) Influence of age and body mass on the effects of vitamin D on hip fracture risk. Osteoporosis Int 5:450–454

    Article  CAS  Google Scholar 

  38. Chapuy MC, Arlot ME, Duboeuf F, Brun J, Crouzet B, Arnaud S, Delmas PD, Meunier PJ (1992) Vitamin D3 and calcium prevent hip fractures in elderly women. N Engl J Med 327:1737–1742

    Article  Google Scholar 

  39. Heikinheimo RJ, Inkovaara JA, Harju EJ (1992) Annual injection of vitamin D and fractures of aged bones. Calcif Tissue Int 51:105–110

    Article  CAS  PubMed  Google Scholar 

  40. Khaw K-T, Sneyd M-J, Compston J (1992) Bone density, parathyroid hormone and 25-hydroxyvitamin D concentrations in middle-aged women. Br Med J 305:273–277

    Article  CAS  Google Scholar 

  41. Kanis JA, Cooper C, Francis R, Hamdy N, Selby P, Torgerson D (1993) The role of vitamin D and related compounds in the treatment of bone disease in the elderly. Bone 15:727–728

    Article  Google Scholar 

  42. Torgerson D, Kanis JA (1995) The cost effectiveness of preventing hip fractures using vitamin D and calcium. Quart Med J 88:135–139

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. WHO Collaborating Centre for Metabolic Bone Diseases, Department of Human Metabolism & Clinical Biochemistry, University of Sheffield Medical School, Beech Hill Road, S10 2RX, Sheffield, UK

    J. A. Kanis

Authors
  1. J. A. Kanis
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kanis, J.A. Vitamin D analogs: From renal bone disease to osteoporosis. Calcif Tissue Int 60, 106–110 (1997). https://doi.org/10.1007/s002239900196

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s002239900196

Key words

Search

Navigation