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Effect of transepithelial concentration gradients on the passive fluxes of sodium across toad bladder

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Summary

Bidirectional sodium fluxes across toad bladder were measured after eliminating active transport with ouabain. Mucosal sodium concentration,C m , was progressively reduced (from 114 to 3mm) while serosal sodium remained constant. Potential difference was maintained at zero by current passage. The ratio,Q, of the bulk permeability coefficient for sodium,P, to the tracer sodium permeability coefficientP *, was found to remain constant asC m decreased. Equations were derived on this basis for bidirectional fluxes and forP andP * as functions ofC m , which corresponded closely to the observed data. The explanation for the observed value ofQ and its constancy under these conditions is uncertain.

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References

  1. Chen, J.S., Walser, M. 1974. Passive ion fluxes across toad bladder.J. Membrane Biol. 18:365

    Google Scholar 

  2. Chen, J.S., Walser, M. 1975. Sodium fluxes through the active transport pathway in toad bladder.J. Membrane Biol. 21:87

    Google Scholar 

  3. DeSousa, R.C., Li, J.H., Essig, A. 1971. Flux ratios and isotopic interaction in an ion exchange membrane.Nature (London) 231:44

    Google Scholar 

  4. Kedem, O., Essig, A. 1965. Isotope flows and flux ratios in biological membranes.J. Gen. Physiol. 48:1047

    PubMed  Google Scholar 

  5. Krämer, H., Meares, P. 1969. Correlation of electrical and permeability properties of ion-selective membranes.Biophys. J. 9:1006

    PubMed  Google Scholar 

  6. Li, J.H., DeSousa, R.C., Essig, A. 1974. Kinetics of tracer flows and isotope interaction in an ion exchange membrane.J. Membrane Biol. 19:93

    Google Scholar 

  7. Reuss, L., Finn, A.L. 1975. Effects of changes in the composition of mucosal solution on the electrical properties of the toad urinary bladder epithelium.J. Membrane Biol. 20:191

    Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacology and Experimental Therapeutics, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, 21205, Baltimore, Maryland

    Jing S. Chen &  Mackenzie Walser

  2. Department of Medicine, 725 North Wolfe Street, 21205, Baltimore, Maryland

    Jing S. Chen &  Mackenzie Walser

Authors
  1. Jing S. Chen
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  2. Mackenzie Walser
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Chen, J.S., Walser, M. Effect of transepithelial concentration gradients on the passive fluxes of sodium across toad bladder. J. Membrain Biol. 27, 381–391 (1976). https://doi.org/10.1007/BF01869147

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  • DOI: https://doi.org/10.1007/BF01869147

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