Abstract
The research was undertaken to analyze the uptake and distribution of cadmium-109 in mice following repeated injections and to observe how the simultaneous administrations of zinc affected the cadmium retention. Mice were given one, two, or three intravenous administrations at 48-hr intervals. Animals were sacrificed 2 min to 48 hr after each injection. Zinc had little effect on the retention of cadmium in the samples analyzed, and injections behaved independently of each other.
Similar content being viewed by others
References
Berlin, M., and S. Ullberg: The fate of cadmium-109 in the mouse. Arch Environ. Health7 686 (1963).
Browning, E.: Toxicity of industrial metals. New York: Appleton-Century Crofts (1969).
Decker, C. F., R. U. Byerrum, and C. A. Hoppert: A study of the distribution and retention of cadmium-115 in the albino rat. Arch. Biochem. Biophys.66 140 (1957).
Dyer, R. D.: M. S. Thesis. Purdue University (1973).
Friberg, L., M. Piscator, and G. Norberg: Cadmium in the environment. Cleveland: Chemical Rubber Company (1971).
Gunn, S. A., and T. C. Gould: Selective accumulation of cadmium-115 by cortex of rat kidney. Proc. Soc. Exp. Biol. Med.96 820 (1957).
Gunn, S. A., T. C. Gould, and W. A. D. Anderson: Mechanisms of zinc, cysteine, and selenium protection against cadmium induced vascular injury to mouse testes. J. Reprod. Fertil.15 65 (1968).
Horner, D. B., and J. C. Smith: The distribution of tracer doses of cadmium in the normal rat. Arch. Environ. Contam. Toxicol.3 307 (1975).
Lucis, O. J., M. E. Lynk, and R. Lucis: Turnover of cadmium-109 in rats. Arch. Environ. Health18 307 (1969).
Miller, W. J., D. M. Blackmon, and Y. G. Martin: Cadmium-109 absorption, excretion, and tissue distribution following single oral and intravenous doses in young goats. J. Dairy Sci.51 1836 (1968).
Schroeder, H. A., and J. J. Balassa: Abnormal trace metals in man: Cadmium. J. Chronic Dis.14 236 (1961).
Schroeder, H. A., A. P. Nason, I. H. Tipton, and J. J. Balassa: Essential trace metals in man: Zinc. Relation to environmental cadmium. J. Chron. Dis.20 179 (1967).
Shanbaky, M. M.: M.S. Thesis. Purdue University (1973).
Shank, K. E., and R. J. Vetter: The effects of copper, mercury, and zinc on the uptake and distribution of cadmium-115m in the albino rat. Environ. Letters6 13 (1974).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Shank, K.E., Vetter, R.J. & Ziemer, P.L. Uptake and distribution of cadmium in mice following repeated administrations. Arch. Environ. Contam. Toxicol. 6, 63–68 (1977). https://doi.org/10.1007/BF02097750
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02097750