Summary
Pulmonary to systemic flow ratios (Qp/Qs) were estimated by quantitative radionuclide angiocardiography (QRAC) in 135 children. The Qp/Qs ratios were derived from pulmonary time/activity curves using a gamma variate model.
Eighty-five of these children also had Qp/Qs ratios estimated by oximetry at cardiac catheterization. Left-to-right shunts with a Qp/Qs range of 1.2 to 3.0 were detected and quantitated by radionuclide angiography with an accuracy similar to that for oximetry. The correlation between Qp/Qs, determined by QRAC and by oximetry was good (r=.93; SEE .31). This relatively noninvasive technique has now been used to estimate the Qp/Qs ratio in 34 children with a clinically suspected left-to-right shunt, and postoperatively in 16 cases with residual murmurs; it has obviated the need for catheterization in many of these patients. The technique may also be used serially to determine changes in the Qp/Qs ratio in patients with known left-to-right shunts.
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References
Alazraki NP, Ashburn WL, Hagan A, Friedman WF: Detection of left to right cardiac shunts with the scintillation camera pulmonary dilution curve.JNM 13:143–147, 1972
Alderson PO, Douglass KH, Mendenhall KG, Guadiani VA, Links JM, Watson DA, Wagner HW Jr: Deconvolution analysis in radionuclide quantitation of left to right cardiac shunts.JNM 20:502–506, 1979
Alderson PO, Jost RG, Strauss AW, Boonvisut S, Markham J: Radionuclide angiocardiography: Improved diagnosis and quantitation of left to right shunts using area ratio techniques in children.Circulation 51:1136–1143, 1975
Askenazi J, Ahnberg DS, Korngold E, LaFarge CG, Maltz DL, Treves S: Quantitative radionuclide angiocardiography: Detection and quantitation of left to right shunts.Am J Cardiol 37:382–387, 1976
Folse R, Braunwald E: Pulmonary vascular dilution curves recorded by external detection in the diagnosis of left to right shunts.Br Heart J 24:166–172, 1962
Hagan AD, Friedman WF, Ashburn WL, Alazraki N: Further applications of scintillation scanning techniques to the diagnosis and management of infants and children with congenital heart disease.Circulation 45:858–868, 1972
Maltz DL, Treves S: Quantitative radionuclide angiocardiography: Determination of Qp/Qs in children.Circulation 47:1049–1056, 1973
McIlveen BM, Höschl R, Murray IPC, McCredie RM, Chidiac P, Marriott D, Beveridge J: Radionuclide quantitation of left to right cardiac shunts in children.Aust NZ J Med 8:500–508, 1978
Stocker FP, Kinser J, Weber JW, Rösler H: Pediatric radiocardioangiography: Shunt diagnosis.Circulation 47:819–826, 1973
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Smallhorn, J.F., Adams, A.P.S., Goldblatt, E. et al. Quantitative radionuclide angiocardiography for left-to-right cardiac shunts in children. Pediatr Cardiol 3, 1–5 (1982). https://doi.org/10.1007/BF02082322
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DOI: https://doi.org/10.1007/BF02082322