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Ejecting volume, filling volume and stroke volume gains: New indexes of inotropism and lusitropism

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Summary

We propose new indexes to evaluate the effects of ventricular inotropism and lusitropism on stroke volume. The end-systolic pressure-volume relationship (ESPVR) or its slope (Emax) has been employed to assess ventricular inotropism. The end-diastolic pressure-volume relationship (EDPVR) or compliance has been used to express ventricular diastolic properties or lusitropism. However, their net effect on stroke volume under a given set of preload and afterload pressures has not quantitatively been evaluated.Ejecting volume gain (Ge) was proposed to quantify the inotropic effect on stroke volume by the change in end-systolic volume between the two ESPVR curves obtained before and during an inotropic intervention at a specified ejecting pressure. Ge is a function of afterload pressure.Filling volume gain (Gf) was proposed to quantify the lusitropic effect on stroke volume by the change in end-diastolic volume between the two EDPVR curves before and during a lusitropic intervention at a specified filling pressure. Gf is a function of preload pressure. The net effect of these inotropic and lusitropic effects on stroke volume at these specified preload and afterload pressures can be expressed by the sum of Ge and Gf. We call this sumstroke volume gain (Gsv). Gsv is a function of preload and afterload pressures. Using representative examples, we demonstrate that these new indexes are conceptually useful to quantitatively understand changes in the pumping ability of the heart under simultaneous inotropic and lusitropic effects as a function of ejecting and filling pressures.

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Authors and Affiliations

  1. Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, Osaka, Japan

    Toshiyuki Takasago, Yoichi Goto, Shiho Futaki, Yuichi Ohgoshi, Hitoshi Yaku, Osamu Kawaguchi, Katsuya Hata, Akio Saeki, Tad W. Taylor & Takehiko Nishioka

  2. The Second Department of Physiology, Okayama University Medical School, Okayama, Japan

    Hiroyuki Suga

Authors
  1. Toshiyuki Takasago
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  2. Yoichi Goto
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  3. Shiho Futaki
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  4. Yuichi Ohgoshi
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  5. Hitoshi Yaku
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  6. Osamu Kawaguchi
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  7. Katsuya Hata
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  8. Akio Saeki
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  9. Tad W. Taylor
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  10. Takehiko Nishioka
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  11. Hiroyuki Suga
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Takasago, T., Goto, Y., Futaki, S. et al. Ejecting volume, filling volume and stroke volume gains: New indexes of inotropism and lusitropism. Heart Vessels 7, 57–65 (1992). https://doi.org/10.1007/BF01744450

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  • DOI: https://doi.org/10.1007/BF01744450

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