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Effectiveness of glycyrrhizin for oral lichen planus in patients with chronic HCV infection

  • Liver, Pancreas, and Biliary Tract
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Abstract

Oral lichen planus (OLP), an intractable inflammatory disease characterized by a band-like lymphocytic invasion under the oral mucosa, is frequently associated with hepatitis C virus (HCV) infection. We investigated the effects of glycyrrhizin, which is used to treat chronic liver dysfunction, in nine patients with OLP who were positive for HCV antibody and HCV RNA. A control group, eight patients with OLP who were also positive for HCV antibody and HCV RNA, was given only dental cleaning. Glycyrrhizin (GL) was given intravenously, at a dose of 40ml (0.2% solution) daily, for 4 consecutive weeks. Six (66.7%) of the nine patients given GL improved clinically (P=0.0141 vs non-GL group), suggesting that GL is useful in treating OLP.

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Authors and Affiliations

  1. Department of Oral Surgery, Kurume University School of Medicine, Kurume, 830, Fukuoka, Japan

    Yumiko Nagao & Tadamitsu Kameyama

  2. Second Department of Medicine, Kurume University School of Medicine, Kurume, 830, Fukuoka, Japan

    Michio Sata, Hiroshi Suzuki & Kyuichi Tanikawa

  3. Department of Immunology, Kurume University School of Medicine, Kurume, 830, Fukuoka, Japan

    Kyogo Itoh

Authors
  1. Yumiko Nagao
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  2. Michio Sata
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  3. Hiroshi Suzuki
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  4. Kyuichi Tanikawa
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  5. Kyogo Itoh
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  6. Tadamitsu Kameyama
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Nagao, Y., Sata, M., Suzuki, H. et al. Effectiveness of glycyrrhizin for oral lichen planus in patients with chronic HCV infection. J Gastroenterol 31, 691–695 (1996). https://doi.org/10.1007/BF02347618

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  • DOI: https://doi.org/10.1007/BF02347618

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