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Tumor-detecting capacity and clinical usefulness of SPIO-MRI in patients with hepatocellular carcinoma

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Abstract:

The tumor-detecting capacity and clinical usefulness of superparamagnetic iron oxide (SPIO) magnetic resonance imaging (MRI) were examined in patients with hepatocellular carcinoma. The tumor detection rate of SPIO-MRI (64.5%) was comparable to those of dynamic computed tomography (CT) and plain MRI, but lower than that for Gd dynamic MRI (93.5%; P < 0.01%). A combination of Gd dynamic MRI and SPIO-MRI improved the detection rate; further, the tumor stage with respect to tumor blood-flow pattern was predicted by combining plain MRI with SPIO-MRI. This combination procedure may also be useful for selecting therapeutic strategies.

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Authors and Affiliations

  1. Fifth Department of Internal Medicine, Tokyo Medical University Kasumigaura Hospital, 3-20-1 Ami-cho chuo, Ibaraki 300-0395, Japan, , , , , , JP

    Hiroshi Nakamura, Yuji Mizokami & Takeshi Matsuoka

  2. Department of Radiology, Tokyo Medical University, Tokyo, Japan, , , , , , JP

    Naoki Ito & Fumio Kotake

Authors
  1. Hiroshi Nakamura
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  2. Naoki Ito
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  3. Fumio Kotake
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  4. Yuji Mizokami
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  5. Takeshi Matsuoka
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Received: November 26, 1999 / Accepted: June 23, 2000

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Nakamura, H., Ito, N., Kotake, F. et al. Tumor-detecting capacity and clinical usefulness of SPIO-MRI in patients with hepatocellular carcinoma. J Gastroenterol 35, 849–855 (2000). https://doi.org/10.1007/s005350070022

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  • DOI: https://doi.org/10.1007/s005350070022

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