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Specific detection of Epstein-Barr virus in inflammatory pseudotumor of the spleen in a patient with a high serum level of soluble IL-2 receptor

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Abstract:

A case of inflammatory pseudotumor of the spleen is described in a 63-year-old woman who presented with an intrasplenic tumor and an elevated serum level of soluble interleukin 2 receptor (sIL-2R). Microscopic examination after removal of the spleen revealed that the tumor was composed of mixed cellular infiltrates, mainly lymphocytes and plasma cells, and spindle-cell proliferation. Epstein-Barr virus (EBV) was specifically detected in the tumor by in situ hybridization for EBV RNA. The serum level of sIL-2R level was normalized after splenectomy. EBV infection may play a role in the development of splenic inflammatory pseudotumor and the elevation of sIL-2R level.

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Authors and Affiliations

  1. Department of Surgery, Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Aoba-ku, Yokohama 227-8501, Japan, , , , , , JP

    Masahiko Yamaguchi, Tadashi Matsumoto, Akihiko Matsumiya, Masaoh Kuzume, Yutaka Sanada & Kaoru Kumada

  2. Department of Clinical Pathology, Showa University Fujigaoka Hospital, Yokohama, Japan, , , , , , JP

    Takako Yamamoto

  3. Department of Pathology, Showa University Fujigaoka Hospital, Yokohama, Japan, , , , , , JP

    Genshu Tate

Authors
  1. Masahiko Yamaguchi
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  2. Takako Yamamoto
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  3. Genshu Tate
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  4. Tadashi Matsumoto
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  5. Akihiko Matsumiya
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  6. Masaoh Kuzume
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  7. Yutaka Sanada
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  8. Kaoru Kumada
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Received: May 27, 1999 / Accepted: November 26, 1999

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Yamaguchi, M., Yamamoto, T., Tate, G. et al. Specific detection of Epstein-Barr virus in inflammatory pseudotumor of the spleen in a patient with a high serum level of soluble IL-2 receptor. J Gastroenterol 35, 563–566 (2000). https://doi.org/10.1007/s005350070082

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  • DOI: https://doi.org/10.1007/s005350070082

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