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Malignancy and viability of intraparenchymal brain tumours: Correlation between Gd-DTPA contrast MR Images and proliferative potentials

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Summary

The feasibility of diagnosing the malignancy and viability of intraparenchymal brain tumours using Gd-DTPA, enhanced and unenhanced T1-weighted MRIs was investigated. The relationship between the Gd-DTPA enhancement pattern, the growth fraction (GF) determined by using the anti-bromode-oxyuridine (BrdU) monoclonal antibody, the clinical condition, the proliferative potential and the change of Gd-DTPA enhancement over time was studied.

Forty-five patients with intracranial tumours were studied with the static method of Gd-DTPA MRI. The enhanced effect in Gd-DTPA MRIs was dependent on tumour-cell density, vascularization, necrosis, and dilatation of vascular lumen. Tumour-cells were observed in eighty-seven of eighty-nine specimens taken from areas with Gd-DTPA enhanced MRIs. Seventy-four percent of these specimens (64 of 87) showed a malignancy of more than 5% growth fraction. On the other hand, tumour cells were observed in twentyseven of fifty-six specimens taken from areas with Gd-DTPA unenhanced MRIs. Eighty-five percent of these specimens (23 of 27) showed a malignancy value of less than 5% GF. However, fifteen percent of these specimens showed values between 5 and 15% GF.

In the kinetic study of Gd-MRIs five patients who were in a clinically stable condition and one patient who had radionecrosis showed a constant pattern of enhancement or slightly increased enhancement 30 min after injection compared to 4 min after injection.

Therefore, GD-DTPA MRI can be used effectively in the diagnosis of tumour viability and malignancy after treatment.

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Authors and Affiliations

  1. Department of Neurological Surgery, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan

    Y. Yoshii, Y. Komatsu, T. Yamada, A. Hyodo, T. Nose & E. Kobayashi

  2. Department of Neurosurgery, Tsukuba Memorial Hospital, Ibaraki, Japan

    E. Kobayashi

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  1. Y. Yoshii
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  2. Y. Komatsu
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  3. T. Yamada
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  4. A. Hyodo
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  5. T. Nose
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  6. E. Kobayashi
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Yoshii, Y., Komatsu, Y., Yamada, T. et al. Malignancy and viability of intraparenchymal brain tumours: Correlation between Gd-DTPA contrast MR Images and proliferative potentials. Acta neurochir 117, 187–194 (1992). https://doi.org/10.1007/BF01400619

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