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Changes in serum cytokine concentrations after neurosurgical procedures

  • Experimental Research
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Summary

Cytokine responses to surgical trauma have been studied in 70 patients undergoing various neurosurgical procedures. Serum concentrations of interleukin-1ß (IL-1ß), interleukin-6 (IL-6), interleukin-8, (IL-8), tumour necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) were measured before and after surgery using enzyme-linked immunosorbent assays.

The serum concentrations of IL-1ß, IL-8, TNF-α, and IFN-γ did not change significantly following neurosurgical operations. In contrast, serum IL-6 levels were significantly elevated following surgery, peaking at postoperative day 1 and then gradually decreasing. Maximum IL-6 concentrations were considerably higher in patients who underwent surgery for brain tumours or aneurysms as compared with patients who had a ventriculoperitoneal shunt, neurovascular decompression or transsphenoidal adenomectomy. Intra-operative use of methylprednisolone, which is known to block the production and action of cytokines, suppressed the increase in IL-6 levels after surgery. There was a statistically significant correlation between the IL-6 peak concentration and the length of surgery in patients not treated with steroids, but not in patients treated with steroids. Additionally patients who underwent supratentorial surgery had higher peak concentrations of IL-6 than those who underwent infratentorial surgery. These results suggest that IL-6 is an early marker of tissue damage and may be useful in assessing the extent of postoperative stress.

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References

  1. Adams EF, Rafferty B, Mower J, Ward H, Petersen B, Fahlbusch R (1994) Human acoustic neuromas secrete interleukin-6 in cell culture: possible autocrine regulation of cell proliferation. Neurosurgery 35: 434–438

    PubMed  Google Scholar 

  2. Andus T, Geiger T, Hirano T, Northoff H, Ganter U, Bauer J, Kishimoto T, Heinrich PC (1987) Recombinant human B cell stimulatory factor 2 (BSF-2/IFM β 2) regulates β-fibrinogen and albumin mRNA levels in Fao-9 cells. FEBS Lett 221: 18–22

    PubMed  Google Scholar 

  3. Baigrie RJ, Lamont PM, Dallman M, Morris PJ (1991) The release of interleukin-1 β (IL-1) precedes that of interleukin-6 (IL-6) in patients undergoing major surgery. Lymphokine Cytokine Res 10: 253–256

    PubMed  Google Scholar 

  4. Baigrie RJ, Lamont PM, Kwiatkowski D, Dallman MJ, Morris PJ (1992) Systemic cytokine response after major surgery. Br J Surg 79: 757–760

    PubMed  Google Scholar 

  5. Braun JM, Gross MA (1989) Cytokines, sepsis and the surgeon. Surg Gynecol Obstet 169: 568–575

    PubMed  Google Scholar 

  6. Castell JV, Andus T, Kunz D, Heinrich PC (1989) Interleukin-6. The major regulator of acute-phase protein synthesis in man and rat. Ann NY Acad Sci 557: 87–99

    PubMed  Google Scholar 

  7. Constantini S, Cotev S, Rappaport ZH, Pomeranz S, Shalit MN (1988) Intracranial pressure monitoring after elective intracranial surgery. J Neurosurg 69: 540–544

    PubMed  Google Scholar 

  8. Cruickshank AM, Fraser WD, Burns HJG, Van Damme J, Shenkin A (1990) Response of serum interleukin-6 in patients undergoing elective surgery of varying severity. Clin Sci 79: 161–165

    PubMed  Google Scholar 

  9. Dinarello CA (1984) Interleukin-1. Rev Infect Dis 6: 51–95

    PubMed  Google Scholar 

  10. Gauldie J, Richards C, Harnish D, Lansdorp P, Baumann H (1987) Interferon β2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells. Proc Natl Acad Sci USA 84: 7251–7255

    PubMed  Google Scholar 

  11. Hall ED (1992) The neuroprotective pharmacology of methylprednisolone. J Neurosurg 76: 13–22

    PubMed  Google Scholar 

  12. Hariri RJ, Chang VA, Barie PS, Wang RS, Sharif SF, Ghajar JBG (1994) Traumatic injury induces interleukin-6 production by human astrocytes. Brain Res 636: 139–142

    PubMed  Google Scholar 

  13. Kloosterman T, Mary B, Von Blomberg E, Borgstein P, Cuesta MA, Scheper RJ, Meijer S (1994) Unimpaired immune functions after laparoscopic cholecystectomy. Surgery 115: 424–428

    PubMed  Google Scholar 

  14. Marinkovic S, Jahreis GP, Wong GG, Baumann H (1989) IL-6 modulates the synthesis of a specific set of acute phase plasma proteins in vivo. J Immunol 142: 808–812

    PubMed  Google Scholar 

  15. Mathiesen T, Andersson B, Loftenius A, von Holst H (1993) Increased interleukin-6 levels in cerebrospinal fluid following subarachnoid hemorrhage. J Neurosurg 78: 562–567

    PubMed  Google Scholar 

  16. Murata A, Ogawa M, Yasuda T, Nishijima J, Oka W, Ohmachi Y, Hikaoka Net al (1990) Serum interleukin 6, C-reactive protein and pancreatic secretory trypsin inhibitor (PSTI) as acute phase proteins after major thoraco-abdominal surgery. Immunol Invest 19: 271–278

    PubMed  Google Scholar 

  17. Oka Y, Murata A, Nishijima J, Yasuda T, Hiraoka N, Ohmachi Y, Kitagawa Ket al (1992) Circulating interleukin 6 as a useful marker for predicting postoperative complications. Cytokine 4: 298–304

    PubMed  Google Scholar 

  18. Pullicino EA, Carli F, Poole S, Rafferty B, Mlik STA, Elia M (1990) The relationship between the circulating concentrations of interleukin-6 (IL-6), tumor necrosis factor (TNF) and the acute phase response to elective surgery and accidental injury. Lymphokine Res 9: 231–238

    PubMed  Google Scholar 

  19. Rock CS, Coyle SM, Keogh CN, Lazarus DD, Hawes AS, Leskiw M, Moldawer LL, Stein TP, Lowry SF (1992) Influence of hypercortisolemia on the acute-phase protein response to endotoxin in humans. Surgery 112: 467–474

    PubMed  Google Scholar 

  20. Roumen RMH, Hendriks T, Jongekrijg JV, Nieuwenhuijzen GAP, Suerwein RW, Meer JWM, Goris RJA (1993) Cytokine patterns in patients after major vascular surgery, hemorrhagic shock, and severe blunt trauma. Ann Surg 218: 769–776

    PubMed  Google Scholar 

  21. Roumen RMH, van Meurs P, Kuypers HHC, Kraak WAG, Sauerwein RW (1992) Serum interleukin-6 and C reactive protein responses in patients after laparoscopic or conventional cholecystectomy. Eur J Surg 158: 541–544

    PubMed  Google Scholar 

  22. Sakamoto K, Arakawa H, Mita S, Ishiko T, Ikei S, Egami H, Hisano S, Ogawa M (1994) Elevation of circulating interleukin 6 after surgery: factors influencing the serum level. Cytokine 6: 181–186

    PubMed  Google Scholar 

  23. Shalaby MR, Waage A, Aarden L, Espevik T (1989) Endotoxin, tumor necrosis factor-alpha and interleukin-1 induce interleukin-6 production in vivo. Clin Immunol Immunopathol 53: 488–498

    PubMed  Google Scholar 

  24. Tarkowski E, Rosengren L, Blomstrand C, Wikkelsö C, Jensen C, Ekholm S, Tarkowski A (1995) Early intrathecal production of interleukin-6 predicts the size of brain lesion in stroke. Stroke 26: 1393–1398

    PubMed  Google Scholar 

  25. Tobler A, Meier R, Seitz M, Dewald B, Baggiolini M, Fey MF (1992) Glucocorticoids downregulate gene expression of GMCSF, NAP-1/IL-8, and IL-6, but not of M-CSF in human fibroblasts. Blood 79: 45–51

    PubMed  Google Scholar 

  26. Todo T, Adams EF, Rafferty B, Fahlbusch R, Dingermann T, Werner H (1994) Secretion of interleukin-6 by human meningioma cells: possible autocrine inhibitory regulation of neoplastic cell growth. J Neurosurg 81: 394–401

    PubMed  Google Scholar 

  27. Tosatu G, Jones KD (1990) Interleukin-1 induces interleukin-6 production in peripheral blood monocytes. Blood 75: 1305–1310

    PubMed  Google Scholar 

  28. Tsang TM, Tam PKH (1994) Cytokine response of neonates to surgery. J Pediatr Surg 29: 794–797

    PubMed  Google Scholar 

  29. Ueno H, Honda M, Adachi M, Inoue H, Nakashima H, Arinaga S, Akiyosi T (1994) Minimal increase in serum interleukin-6 levels during laparoscopic cholecystectomy. Am J Surg 168: 358–360

    PubMed  Google Scholar 

  30. Van Zee KJ, Deforge LE, Fischer E, Marano MA, Kenney JS, Remick DG, Lowry SF, Moldawer LL (1991) IL-8 in septic shock, endotoxemia, and after IL-1 administration. J Immunol 146: 3478–3482

    PubMed  Google Scholar 

  31. Waage A, Slupphaug G, Shalaby R (1990) Glucocorticoids inhibit the production of IL-6 from monocytes, endothelial cells and fibroblasts. Eur J Immunol 20: 2439–2443

    PubMed  Google Scholar 

  32. Woodroofe MN, Sarna GS, Wadhwa M, Hayes GM, Loughlin AJ, Tinker A, Cuzner ML (1991) Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: evidence of a role for microglia in cytokine production. J Neuroimmunol 33: 227–236

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Neurosurgery, Nagoya University School of Medicine, Nagoya, Japan

    K. Osuka, Y. Suzuki, K. Saito, M. Takayasu & M. Shibuya

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  1. K. Osuka
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  2. Y. Suzuki
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  3. K. Saito
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  4. M. Takayasu
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  5. M. Shibuya
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Osuka, K., Suzuki, Y., Saito, K. et al. Changes in serum cytokine concentrations after neurosurgical procedures. Acta neurochir 138, 970–976 (1996). https://doi.org/10.1007/BF01411287

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