Summary
In 47 patients with various pituitary tumours plasma cortisol, LH, FSH, prolactin, and GH were measured by radioimmunoassays to investigate anterior pituitary function. In 14 subjects LH-RH and TRH stimulation tests were performed to assess pituitary reserve before, during, and after surgical therapy. The mean cortisol levels were raised during and after the operative procedures until the 14th postoperative days. In patients with functionless tumours the other hormone concentrations remained nearly unchanged and in the normal ranges. After the removal of the tumour a rapid decrease in hormone levels, as might be expected, was rare, with the exception of the GH and prolactin levels in patients with hypersecretion. The postoperative stimulation tests showed a maintained secretory pituitary reserve due to active tissue left behind after operative removal of the tumour.
Similar content being viewed by others
References
Althoff, P. H., Happ, J., Grabs, V., Schneider, B., Beyer, J., Schöffling, K., The early rise of growth hormone in acromegalic patients following intravenous glucagon-sign of secondary hypothalamic acromegaly? Acta endocr. (Kbh.) Suppl.184 (1974), 7.
Arseni, C., Maretsis, M., Craniopharyngioma. Neurochirurgica1 (1972), 25–32.
Asfeldt, V. H., Elb, S., Hypothalamo-pituitary-adrenal response during major surgical stress. Acta endocr. (Kbh.)59 (1968), 67–75.
Basso, A., Guitelman, A., Amezua, L., Molocznik, I., Mancini, A., Montez, M., Adénome de l'hypophyse à prolactine. Possibilités actuelles de diagnostic et de traitement. Neuro-Chirurgie21 (1975), 111–120.
Beks, W. F., Doorenbos, H., Walstra, G. J. M., Clinical experiences with steroids in neurological patients. In: Steroids and brain edema (eds. H. J. Reulen, K. Schürmann), pp. 233–238. Berlin-Heidelberg-New York: Springer. 1972.
Besser, G. M., Mortimer, C. H., Hypothalamic regulatory hormones: a review. J. clin. Path.27 (1974), 173–184.
Bouzarth, W. F., Shenklin, H. A., Gutterman, P., Adrenal cortical response to neurosurgical problems, noting the effects of exogenous steroids. In: Steroids and brain edema (eds. H. J. Reulen, K. Schürmann), pp. 183–193. Berlin-Heidelberg-New York: Springer. 1972.
Child, D. F., Nader, S., Mashiter, K., Kjeld, M., Banks, L., Fraser T. Russell, Prolactin studies in “functionless” pituitary tumours. Brit. Med. J.1 (1975), 604–606.
Coscia, A. M., Fleischer, N., Besch, P. K., Brown, L. P., Desiderio, D., The effect of synthetic luteinizing hormonereleasing factor on plasma LH levels in pituitary disease. J. Clin. Endocrin. Metab.38 (1974), 83–88.
Guiot, G., Thibaut, B., L'extirpation des adénomes hypophysaires par voi trans-sphénoidale. Neurochir.1 (1959), 133–150.
Hardy, J., Transsphenoidal microsurgical removal of pituitary adenoma. In: Recent Progress in Neurological Surgery. Amsterdam: Excerpta Medica. 1974.
Klar, E., Bericht über 456 Hypophysenausschaltungen (472 Eingriffe) mittels Elektrokoagulation bzw. Radio-Gold-Implantation auf percutanem, paranasalem Wege. Langenbecks Arch. klin. Chir.294 (1960), 497–510.
Kley, H. K., Wiegelmann, W., Solbach, H. G., Krüskemper, H. L., Kombinierter Stimulationstest zur Simultananalyse mehrerer Partialfunktionen der Adenohypophyse. Dtsch. med. Wschr.99 (1974), 2014–2027.
Kracht, J., Hachmeister, U., Hormonbildungsstätten im Hypophysenvorderlappen des Menschen. In: Oestrogene, Hypophysentumoren (Hrsg. J. Kracht), S. 200–205. Berlin-Heidelberg-New York: Springer. 1969.
Labhart, A., Die Adenohypophyse. In: Klinik der inneren Sekretion, 2. Aufl. (Hrsg. A. Labhart), S. 70–129. Berlin-Heidelberg-New York: Springer. 1971.
Landolt, A. M., Hosbach, H. U., Biological aspects of pituitary tumors as revealed by electron microscopy. Pathologica66 (1974), 413–436.
Malarkey, W. B., Beck, P., Twenty-four-hour prolactin profiles in normal and disease states: failure of thyroxine to modify prolactin secretion. J. Clin. Endocrinol. Metab.40 (1975), 708–712.
Mortimer, C. H., Besser, G. M., McNeilly, A. S., Marshall, J. C., Harsoulis, P., Tunbridge, W. M. G., Gomez-Pan, A., Hall, R., Luteinizing hormone and follicle stimulating hormonereleasing hormone test in patients with hypothalamic-pituitary-gonadal dysfunction. Brit. Med. J.4 (1973), 73–77.
Neubauer, M., Retiene, K., Nebennieren. In: Untersuchungsmethoden und Funktionsprüfungen in der inneren Medizin, Bd. II (Hrsg. von H. A. Kühn, H.-G. Lasch), S. 590–616. Stuttgart: G. Thieme. 1975.
Osterman, P. O., Lundberg, P. O., Wide, L., The level and circadian rhythm of plasma free 11-hydroxycorticoids in patients with localized intracranial processes, especially of the sellar region. Acta Neurol. Scandinav.49 (1973), 115–132.
Ray, B. S., Intracranial hypophysectomy. J. Neurosurg.28 (1968), 180–186.
Retiene, K., Neubauer, M., Hypothalamus-Hypophysen-System. In: Untersuchungsmethoden und Funktionsprüfungen in der inneren Medizin, Bd. II(Hrsg. von H. A. Kühn, H.-G. Lasch), S. 531–544. Stuttgart: G. Thieme. 1975.
Reulen, H. J., Hadjidimos, A., Hase, U., Steroids in the treatment of brain edema. In: Advances in neurosurgery, Vol. 1 (eds. K. Schürmann, M. Brock, H. J. Reulen, D. Voth), pp. 92–105. Berlin-Heidelberg-New York: Springer. 1973.
Ruf, H., Über die transfrontale Freilegung der Sellaregion. Dtsch. med. Wschr.95 (1970), 2233–2236.
Schwinn, G., von zur Mühlen, A., Köbberling, J., Halves, E., Wenzel, K. W., Meinhold, H., Plasma prolactin levels after TRH and chlorpromazine in normal subjects and patients with impaired pituitary function. Acta Endocrinol.79 (1975), 663–676.
Scriba, P. C., von Werder, K., Schwarz, K., Hypothalamus und Hypophyse. In: Klinische Pathophysiologie, 2. Aufl. (Hrsg. W. Siegenthaler), S. 266. Stuttgart: G. Thieme. 1973.
Von Wild, K., Hoffmann, F.-D., Neubauer, M., Althoff, P.-H., Happ, J., Hormone concentrations in patients with pituitary tumours in the postoperative period with regard to hormone replacement therapy, pp. 327–337. In: Advances in neurosurgery, Vol. 2(eds. W. Klug, M. Brock, M. Klinger, O. Spoerri). Berlin-Heidelberg-New York: Springer. 1975.
Winkelmann, W., Bethge, H., Hackenberg, K., Solbach, H. G., Cortisol und Corticosteronsekretion bei Hypophysentumoren. In: Oestrogene Hypophysentumoren (Hrsg. J. Kracht), S. 309–311. Berlin-Heidelberg-New York: Springer. 1969.
Zarate, A., Canales, E. S., Villalobos, H., Soria, J., Jacobs, L. S., Kastin, A. J., Schally, A. V., Pituitary hormonal reserve in patients presenting hyperprolactinemia, intrasellar masses, and amenorrhea without galactorrhea. J. Clin. Endocrinol. Metab.40 (1975), 1034–1037.
Zimmermann, H., Solbach, H. G., Wiegelmann, W., Pre- and postoperative hormone substitution in pituitary tumors. In: Modern aspects of neurosurgery, Vol. IV(eds. H. Kuhlendahl, M. Brock, D. Le Vay, T. J. Weston), pp. 191–196. Amsterdam: Excerpta Medica. 1973.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
von Wild, K., Hoffmann, F.D., Neubauer, M. et al. Hypophyseal function in the operative and postoperative phases after removal of pituitary tumours. Acta neurochir 35, 15–26 (1976). https://doi.org/10.1007/BF01405929
Issue Date:
DOI: https://doi.org/10.1007/BF01405929