Summary
Sixty dogs with experimental subarachnoid haemorrhage (SAH), repeated SAH, and subarachnoid fibrosis (examined three weeks and three months after SAH, and treated with urokinase or dexamethasone) were examined by scanning electron microscope (SEM). The authors observed the resting and activated macrophages, the erythrophagocytosis, and giant cells in the subarachnoid space after SAH. They consider that the macrophages play an important role in the formation of subarachnoid fibrosis, similar to the role of macrophages in fibrosis in other sites.
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Barrionuevo, P. J., Dujonvy, M., Kossovsky, N., Laha, R. K., Scanning electron microscopic anatomy of the supratentorial basal cisterns. Neurosurgery3 (1978), 54–60.
Bessis, M., Living blood cells and their ultrastructure, pp. 479–480. Berlin-Heidelberg-New York: Springer. 1973.
Biemesderfer, D., Block, L. H., Male, P., Kashgarian, M., Changes in macrophage surface morphology and erythrophagocytosis induced by ubiquinone-8. In: Scanning electron Microscopy, vol. II (1978), pp. 333–340. SEM Inc., AMF.
Burrell, R., Anderson, M., The induction of fibrogenesis by silica treated alveolar macrophages. Environmental Research6 (1973), 389–394.
Clark, R. A., Stone, R. D., Leung, D. Y. K., Silver, I., Hohn, D. C., Hunt, T. K., Role of macrophages in wound healing. Surg. Forum27 (1976), 16–18.
Gordon, S., Assays for macrophage activation and secretion products. In: Handbook of Experimental Immunology (Weir, D. M., ed.), vol. 2, pp. 33.1–33.14. Oxford: Blackwell Scientific Pub. 1978.
Harington, J. S., Ritchie, M., King, P. C., Miller, K., The in vitro effects of silica treated hamster macrophages on collagen production by hamster fibroblasts. J. Exp. Path.109 (1973), 21–37.
Heppleston, A. G., Styles, J. A., Activity of a macrophage factor in collagen formation by silica. Nature214 (1969), 521–522.
Leibovich, S. J., Ross, R., The role of the macrophage in wound repair. Amer. J. Pathol.78 (1975), 71–91.
Lewis, D. M., Burrel, R., Induction of fibrogenesis by lung antibody-treated macrophages. Brit. J. industr. Med.33 (1976), 25–28.
Malloy, J. J., Low, F. N., Scanning electron microscopy of the subarachnoid space in the dog. IV. Subarachnoid macrophages. J. comp. neurol.167 (1976), 257–283.
Merchant, R., Low, N. L., Scanning electron microscopy of the subarachnoid space in the dog. V. Macrophages challenged by bacillus calmett-Guerin. J. comp. Neurol.172 (1977), 381–408.
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This work was supported by the Japan Society for the Promotion of Science.
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Julow, J., Ishii, M. & Iwabuchi, T. Scanning electron microscopy of the subarachnoid macrophages after subarachnoid haemorrhage, and their possible role in the formation of subarachnoid fibrosis. Acta neurochir 50, 273–280 (1979). https://doi.org/10.1007/BF01808524
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DOI: https://doi.org/10.1007/BF01808524