Skip to main content
SpringerLink
Log in

Activation of the coagulation system in the subarachnoid space after subarachnoid haemorrhage: Serial measurement of fibrinopeptide A and bradykinin of cerebrospinal fluid and plasma in patients with subarachnoid haemorrhage

  • Published:
Acta Neurochirurgica Aims and scope Submit manuscript

Summary

Fibrinopeptide A (FPA) levels as an indicator of thrombin activity in the cerebrospinal fluid (CSF) and plasma of 25 patients with subarachnoid haemorrhage (SAH) were measured serially by radioimmunoassay (RIA). FPA levels in CSF were extremely high on days 0–1 (1253±269 ng/ml, mean ± standard error) but decreased rapidly (11.3±3.9 ng/ml on days 2–4, 10.7±5.9 ng/ml on days 5–7, and 6.3±1.5 ng/ml on days 8–14). In the controls the FPA concentration in CSF was 1.2±0.9 ng/ml (mean ± standard deviation). Plasma FPA levels in patients with SAH showed no statistically significant changes with time.

The bradykinin (BK) concentration in CSF and plasma in 27 patients with SAH was measured serially by RIA. The cocentrations in CSF were 122.7±22.7 pg/ml (mean ± standard error) on day 0, 38.6±6.1 pg/ml on day 1,22.7±6.3 pg/ml on day 2, and 17.1±3.0 pg/ml or less thereafter. Plasma BK levels in patients with SAH were higher than those in the control group, but there was no statistically significant change over time.

From the measurement of FPA it was apparent that the coagulation system in the subarachnoid space is strongly activated in the early stage of SAH. The formation of BK in CSF after SAH is thought to be due to the contact activation of Hageman factor (intrinsic factor) in the subarachnoid space. Trabeculae as collagen bundles in the subarachnoid space were considered to have a possible role in activating the Hageman factor of the coagulation system in SAH.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Abe K, Sakurai Y (1980) Plasma kinin. Clin All-round 29: 2566–2570 (in Japanese)

    Google Scholar 

  2. Anderson M, Matthews KM, Stuart J (1978) Coagulation and fibrinolytic activity of cerebrospinal fluid. J Clin Path 31: 488–492

    PubMed  Google Scholar 

  3. Asai T (1977) The effect of the intraventricular blood component on both the production and absorption rate of cerebrospinal fluid in dog. (Part II) Neurol Med Chir (Tokyo) 17: 493–498 (in Japanese)

    Google Scholar 

  4. Elliotto DF, Lews GP, Horton EW (1960) The structure of bradykinin — a plasma kinin from ox blood. Biochem Biophys Res Commun 3: 87–91

    Google Scholar 

  5. Fisher CM, Kistler JP, Davis JM (1980) Relation of cerebral vasospasm to subarachnoid hemorrhage visualized by computerized tomographic scanning. Neurosurg 6: 1–9

    PubMed  Google Scholar 

  6. Harpel PC (1972) Studies on the interaction between collagen and a plasma kallikrein-like activity. J Clin Invest 51: 1813–1822

    PubMed  Google Scholar 

  7. Hoshi T, Shimizu T, Kito K, Yamasaki N, Takahashi K, Takahashi M, Okada T, Kasuya H, Kitamura K (1984) Immunological study of late cerebral vasospasm in subarachnoid hemorrhage. Detection of immunoglobulins, C3, and fibrinogen in cerebral arterial walls by immunofluorescence method Neurol Med Chir (Tokyo) 24: 647–654 (in Japanese)

    Google Scholar 

  8. Hunt WE, Kosnik EJ (1974) Timing and perioperative care in intracranial aneurysm surgery. Clin Neurosurg 21: 79–89

    PubMed  Google Scholar 

  9. Kariya K, Kawauchi R, Okamoto H (1981) Regional distribution of kininase in rat brain. J Neurochem 36: 2086–2088

    PubMed  Google Scholar 

  10. Kariya K, Yamauchi A, Hattori S, Tsuda Y, Okada Y (1982) The disappearance rate of intraventricular bradykinin in the brain of the conscious rat. Biochem Biophys Res Commun 107: 1461–1466

    PubMed  Google Scholar 

  11. Kizuki K, Moriya H (1986) Biochemical aspects of the kallikreinkinin system — progress and recent topics. J J Inf 6: 221–232 (in Japanese)

    Google Scholar 

  12. Lopes CAS, Mair WGP (1974) Ultrastructure of arachnoid membrane in man. Acta Neuropath (Berlin) 28: 167–173

    Google Scholar 

  13. Maier-Hauff K, Beathmann AJ, Lange M, Schurer L, Unterberg A (1984) The kallinkrein-kinin system as mediator in vasogenic brain edema. J Neurosurg 61: 97–106

    PubMed  Google Scholar 

  14. Mcgiff JC (1980) Interaction of prostaglandins with the kallikrein-kinin and renin-angiotensin systems. Clin Sci 59: 105s-116s

    PubMed  Google Scholar 

  15. Nakahara M (1980) Binding and dissociation of Hageman factor, prekallikrein and high molecular weight kininogen in human plasma during contact activation. Biochem Pharmacol 29: 1247–1254

    PubMed  Google Scholar 

  16. Nasjletti A, Malik KU (1979) Relationship between the kallikrein-kinin and prostaglandin systems. Life Sci 25: 99–110

    PubMed  Google Scholar 

  17. Nossel HL, Ti M, Kaplan KL, Spanondis K, Soland T, Butier VP (1976) The generation of fibrinopeptide A in clinical blood samples, evidence for thrombin activity. J Clin Invest 58: 1136–1144

    PubMed  Google Scholar 

  18. Nossel HL, Jensen AH, Liu CY, Koehn JA, Canfield RE (1983) Molecular biology of fibrinogen and fibrin: Fibrinopeptide release from fibrinogen. Ann N Y Acad Sci 408: 269–278

    PubMed  Google Scholar 

  19. Okada T, Shimizu T, Yamasaki N, Takahashi K, Hoshi T, Kasuya H, Kitamura K (1985) A study on coagulation and fibrinolysis of subarachnoid hemorrhage — by measurement of fibrinopeptide A and fibrinopeptide B beta 15–42 in blood and in cerebrospinal fluid. Igaku No Ayumi 134: 581–582 (in Japanese)

    Google Scholar 

  20. Regoli D, Berabe J (1980) Pharmacology of bradykinin and related kinins. Pharmacol Rev 32: 1–46

    PubMed  Google Scholar 

  21. Rocha e Silva M, Beraldo WT, Rosenfeld G (1949) Bradykinin, a hypotensive and smooth muscle stimulating factor released from plasma globulin by snake venoms and by trypsin. Am J Physiol 156: 261–273

    Google Scholar 

  22. Ryan JW, Roblero J, Stewart JM (1968) Inactivation of bradykinin in the pulmonary circulation. Biochem J 110: 795–797

    PubMed  Google Scholar 

  23. Shimizu T, Kito K, Yamazaki N, Takahashi K, Takahashi M, Yamane K, Sim C, Kitamura K, Sendo S (1982) Immunological study of late cerebral vasospasm in subarachnoid hemorrhage. Neuro Med Chir (Tokyo) 22: 613–619 (in Japanese)

    Google Scholar 

  24. Sicteri F (1968) Treatment of subarachnoid and other intracranial hemorrhages with proteinase inhibitors. Ann N Y Acad Sci 146: 682–700

    PubMed  Google Scholar 

  25. Sicteri F, Fanciullacci M, Bavazzano A, Franchi G, Del Bianco PL (1970) Kinins and intracranial hemorrhages. Angiology 21: 193–210

    PubMed  Google Scholar 

  26. Takanashi N, Ohno Y, Aoyama M, Maruyama I, Okada A, Shinmyozu K, Igata A (1983) Plasma kinins measurement by sensitive kinin radioimmunoassay and its clinical application. Thrombosis and Haemostasis 50: 230

    Google Scholar 

  27. Toda N (1977) Action of bradykinin on isolated cerebral and peripheral arteries. Am J Physiol 232: H267-H274

    PubMed  Google Scholar 

  28. Tovi D, Nilsson IM, Thulin CA (1973) Fibrinolytic activity of the cerebrospinal fluid after subarachnoid hemorrhage. Acta Neurol Scand 49: 1–9

    PubMed  Google Scholar 

  29. Unterberg A, Dautermann C, Beathmann A, Muller-Esteri W (1986) The kallinkrein-kinin system as mediator in vasogenic brain edema, Part 3: Inhibition of the kallikrein-kinin system in traumatic brain swelling. J Neurosurg 64: 269–276

    PubMed  Google Scholar 

  30. Vermeulen M, van Vliet HHDM, Lindsay KW, Hijdra A, Gijn JV (1985) Source of fibrin/fibrinogen degradation products in the CSF after subarachnoid hemorrhage. J Neurosurg 63: 573–577

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurosurgery, Neurological Institute, Tokyo Women's Medical College, Japan

    H. Kasuya, T. Shimizu, T. Okada, K. Takahashi, T. Summerville & K. Kitamura

Authors
  1. H. Kasuya
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. Shimizu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. T. Okada
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. K. Takahashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. T. Summerville
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. K. Kitamura
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kasuya, H., Shimizu, T., Okada, T. et al. Activation of the coagulation system in the subarachnoid space after subarachnoid haemorrhage: Serial measurement of fibrinopeptide A and bradykinin of cerebrospinal fluid and plasma in patients with subarachnoid haemorrhage. Acta neurochir 91, 120–125 (1988). https://doi.org/10.1007/BF01424566

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01424566

Keywords

Search

Navigation