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Positron emission tomographical studies of 1-11C-acetoacetate, 2-18F-fluoro-deoxy-D-glucose, and L-1-11C-tyrosine uptake by cat brain with an experimental lesion

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Summary

In cat brain with a freezing injury, the uptake of 1-11C-acetoacetate (11C-ACAC), 2-18F-fluorodeoxy-D-glucose (18FDG), and L-1-11C-tyrosine (11C-TYR) was monitored by positron emission tomography following intravenous administration of the tracers, at 1 day and 1–3 weeks after the injury. The development and further course of the cold-induced oedema was monitored by magnetic resonance imaging. In the fresh (1 day old) lesion there was increased uptake of11C-ACAC, probably due to release of the restrictive influence of the blood-brain barrier upon passage of the substance into brain. The uptake of18FDG, which normally occurs by carrier-mediated transport at the barrier, was decreased in the fresh lesion, probably as a result of damage of the carrier mechanism. In the 3 week old lesion18FDG uptake was still reduced, and11C-ACAC uptake was still increased, although barrier function to Evans blue had recovered. It is suggested, that the increased11C-ACAC uptake in the chronic lesion bears upon the proliferation of macrophages and reactive glial cells in the lesion. This is supported by the increased uptake of11C-TYR in the 2 weeks old lesion, while in the fresh lesion11C-TYR uptake was unchanged.

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Authors and Affiliations

  1. Department of Neurosurgery, University of Groningen and University Hospital, Groningen, The Netherlands

    G. H. M. Prenen, K. G. Go & F. Zuiderveen

  2. Department of Nuclear Medicine, University of Groningen and University Hospital, Groningen, The Netherlands

    A. M. J. Paans, W. Vaalburg, S. Zijlstra & P. H. Elsinga

  3. Department of Nuclear Magnetic Resonance, University of Groningen and University Hospital, Groningen, The Netherlands

    R. L. Kamman

  4. Department of Pathology, University of Groningen and University Hospital, Groningen, The Netherlands

    W. M. Molenaar

  5. Department of Psychiatry, University of Groningen and University Hospital, Groningen, The Netherlands

    J. B. Sebens & J. Korf

Authors
  1. G. H. M. Prenen
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  2. K. G. Go
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  3. A. M. J. Paans
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  4. F. Zuiderveen
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  5. W. Vaalburg
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  6. R. L. Kamman
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  7. W. M. Molenaar
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  8. S. Zijlstra
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  9. P. H. Elsinga
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  10. J. B. Sebens
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  11. J. Korf
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Prenen, G.H.M., Go, K.G., Paans, A.M.J. et al. Positron emission tomographical studies of 1-11C-acetoacetate, 2-18F-fluoro-deoxy-D-glucose, and L-1-11C-tyrosine uptake by cat brain with an experimental lesion. Acta neurochir 99, 166–172 (1989). https://doi.org/10.1007/BF01402328

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